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Showing 6 results for Sohrabvand

Farnaz Sohrabvand, Mina Jafarabadi,
Volume 3, Issue 2 (7-2005)

Background: Knowledge of infertile couples about assisted reproductive technology is a fundamental parameter to optimize the infertility treatment and conduct it cooperatively. Objective: To evaluate knowledge and attitude of infertile couples about assisted reproductive technology we designed a descriptive cross-sectional study. Materials and Methods: 400 infertile patients were investigated by a self- administered structured questionnaire about demographic data, infertility history, and several relevant variables in an out patient infertility clinic of a university hospital. The main outcome measurements included scoring the answers in the questionnaire regarding knowledge, and grouping the answers regarding attitude. Resulted data were analyzed in relation to patient�s gender and treatment history, and educational, ethnic and religious groups. Results: Of 400 cases (251 women and 149 men) 167 patients (41.7%) were scaled to have good knowledge and 223 patients (55.7%) had a poor knowledge about ART. 74.6% of patients with advanced education and 30.3% of patients without advanced education were scaled to be good in knowledge. 45.6% of men, 43.4% of women and 64.8% of patients with a history of passing previous ART cycles had a good knowledge. The source of information was mentioned to be the ART centers in 73% of cases. 95% of patients disagreed to have sperm or ovum donation or to undergo surrogacy. 22% of all patients (27.5% of women versus 12.1% of men) agreed with embryo reduction. 94.5% of patients mentioned the ART expenses not to be affordable readily. Conclusions: Less than half of patients presented to be knowledgeable about ART. Not a great portion of the patients agreed with sperm donation. ART expense is mentioned to be burdensome by nearly all of the patients.
Farnaz Sohrabvand, Nasrin Abedinia, Reyhaneh Pirjani, Mina Jafarabadi,
Volume 6, Issue 3 (7-2008)

Background: There is increasing evidence that psychological factors like anxiety and depression can affect IVF/ICSI treatment results.
Objective: This study aimed to clarify the role of women’s anxiety and depression on the outcome of ART cycles using Intra Cytoplasmic Sperm Injection (ICSI).
Materials and Methods: This was a prospective pilot study. One hundred six (106) consecutive women undergoing ICSI cycles were enrolled between January 2006 and 2007. Age, duration and cause of infertility, number and score of transferred embryos were recorded for each patient. Data regarding the state of anxiety and depression of each volunteer were collected using the translated and validated Iranian Cattle Anxiety and Beck Depression Inventories.
Results: Among 106 women enrolled in the study, 25 cases (23.5%) of clinical pregnancies occurred. In univariate analysis, there was no significant difference regarding age and cause and duration of infertility between groups. Number of transferred embryos was significantly associated with higher pregnancy rates (3.4± 1.15 vs. 2.5±1.38 in pregnant and nonpregnant group respectively). Among the 106 participants, 73.58% had anxiety and 30.18% showed various degrees of depression. Out of 28 patients with no anxiety, 21(75%) and out of 74 patients with no depression, 24(32%) became pregnant. There was significant association between depression/anxiety and pregnancy rate (p=0.034 and p=0.00 respectively). Logistic regression model showed that anxiety/depression affect the outcome of ART significantly.
Conclusion: It is crucial to identify infertile patients at greater demand for psychological support before starting ART cycles.
Farnaz Sohrabvand, Fedyeh Haghollahi, Masoomeh Maasomi, Leila Asgarpoor, Mamak Shariat, Mahtab Hamedani,
Volume 7, Issue 4 (7-2009)

Background: In spite of the great progress in assisted reproductive techniques ( ART), and although good quality embryos are transferred,  pregnancy rates have remained around 30%-35% due to low implantation rates.
Objective: The aim of this study was to assess and compare the effects of administrating indomethacin or hyoscine suppositories prior to embryo transfer on the pregnancy rate in ART cycles.
Materials and Methods: This double-blind clinical trial was performed in Vali-e-Asr Hospital as a pilot study from August 2005 through December 2006 on 66 infertile women in ART cycles. Controlled ovarian hyperstimulation  was done using recombinant FSH (Gonal-F) with a long GnRH analogue protocol. After obtaining written consent, the subjects were randomly allocated into three  equal groups (n=22). Groups A and B received  indomethacin and hyoscine rectal suppositories, respectively 30 minutes  before embryo transfer and group C was the control group. Data were analyzed by χ2 , t-test, ANOVA, and Kruskall Wallis tests.
Results: Overall pregnancy rate was 31% (n=21) with 13.6% (n=3) in  group A,  45.5% (n=10), and 36% (n=8) in groups B and C respectively, which shows that pregnancy rate is significantly higher in the group using hyoscine compared to  the other two groups (p=0.04). Uterine muscle cramps were experienced by 3 women (13.6%) in group C while none were reported by women in groups A or B, which shows a significant difference (p<0.04).
Conclusion: It seems that  compared to indomethacin, hyoscine administration 30 minutes prior to embryo transfer can significantly increase pregnancy rates  by reducing uterine and cervical muscle spasm.
Farnaz Sohrabvand, Shahrzad Sheikhhassani, Maryam Bagheri, Fedyeh Haghollahi, Maryam Shabihkhani, Mamak Shariat, Manijeh Nasr Esfahani,
Volume 10, Issue 3 (7-2012)

Background: Polycystic ovary syndrome (PCOS) is a common cause of ovulatory disorders and infertility with high LH to FSH ratio. In order to prevent further increase of LH and follicle atresia, different regimens for ovulation induction have been recommended using FSH alone.  
Objective: This study was performed in PCOS patients to compare ART outcomes in cycles induced by FSH alone, using either recombinant or urinary products.  
Materials and Methods: In a randomized trial, from 623 patients who underwent down regulation with GnRH analogue in a long protocol, 160 PCOS patients were randomly divided into two groups of 80. Group A received 150 IU/d recombinant FSH (Gonal-F) and group B 150 IU/d urinary FSH (Fostimon).
Results: 33 cases (41.2%) in group A and 36 (45%) in group B achieved clinical pregnancy, which was not significantly different (p=0.67). Total number of oocytes retrieved (13.03±5.56 vs. 14.17±4.89, p=0.17), quality and number of embryos (7.42±3.35 vs. 7.63±3.28, p=0.68) and OHSS rate were similar in group A compared to group B. Endometrial thickness which was 9.66±1.67 mm in group A and 10.36±1.35 mm in group B, showed a significant difference (p=0.004).
Conclusion: It seems that in PCOS patients, both pure FSH products used for controlled ovarian hyperstimulation have similar effects on ART outcome and can be used according to availability and patient acceptance without significant difference.
Mojgan Tansaz, Roshanak Mokaberinejad, Soodabeh Bioos, Farnaz Sohrabvand, Majid Emtiazy,
Volume 11, Issue 2 (4-2013)

Dear Editor, Estrogen deficiency in women is an important risk factor for serious disorders such as severe cardiovascular diseases (1). Several different conditions can lead to estrogen deficiency with premature ovarian failure (POF) being an important one (2, 3). POF includes the cessation of normal ovarian function before age 40, causing menopausal symptoms and general health problems. Although there are several known causes of ovarian failure i.e chromosomal defects, autoimmune disease, exposure to radiation and certain drugs; but most cases of POF are of unknown etiology. Consequently, further work is required to understand the etiology, possible prevention and treatment of POF (4). The most influential Iranian physician between 9th and 14th centuries AD was Ibn-Sina or Avicenna (980-1037 A.D). He was a great physician and has written more than 335 books on various subjects. His chief medical book is "Al-Qanon fi Al-Tibb" or "The Canon of Medicine" (5). According to "The Canon of Medicine", the basis of health is the right proportion and specific equilibrium of humors (Akhlat) according to their quality and quantity (6). Based on Iranian traditional medicine, there are four humors in the body: "Phlegm, Blood, Yellow bile and Black bile" (7). Each of them is related with a pair of qualities, including cold and wet, hot and wet, hot and dry, and cold and dry, respectively (6). In Iranian traditional medicine, premature ovarian failure is not defined the same as known today, but in many cases, it has been described as a disorder (8). Due to lack of biochemical analysis of blood parameters, almost all disease states have been defined based on clinical symptoms (9). The most obvious manifestation of POF is amenorrhea (10). The twenty-first chapter of third book of Al-Qanon fi Al-Tibb deals, principally with various kinds of uterine diseases. In this section, amenorrhea is described under a different title: "Ehtebase Tams" which means lack of menstruation. Avicenna has stated that one of the major causes of "Ehtebase tams" is abnormal black bile predominance (8). Based on The Canon of Medicine other symptoms that are seen in the "Ehtebase tams" of abnormal black bile predominance are as follows: vaginal dryness, dry eye, dry skin, anxiety, depression, somatization, sensitivity, hostility, forgetfulness, tiredness, headache, appetite disturbance, sleep disorder and depression and less satisfaction with sexual life (8). New studies have proven all of these symptoms (10). Black bile is divided into two categories: normal and abnormal. In contrast to normal black bile, abnormal black bile has affinity to deposit in any tissue and organ. As a consequence, in cases of abnormal black bile predominance, a high level of its deposition in the ovaries can lead to their dysfunction similar to its effect on other organs and tissues (arteries) (5, 7). According to this letter, it seems that the treatment of "black bile predominance” can be used as one of the first steps in treating POF patients. This finding can be used as an important theory to design the prevention and treatment plan of POF based on Iranian traditional medicine text books. Most obviously further clinical study is recommended to investigate this issue.
Tahereh Eftekhar, Farnaz Sohrabvand, Neda Zabandan, Mamak Shariat, Fedyeh Haghollahi, Akram Ghahghaei-Nezamabadi,
Volume 12, Issue 8 (8-2014)

Background: Polycystic Ovary Syndrome (PCOS) is presented with characteristic complications such as chronic an ovulation, obesity, and hyperandrogenism which can affect sexual function in women of reproductive age.
Objective: Herein we evaluated the frequency and predisposing factors of sexual dysfunction in infertile PCOS patients.
Materials and Methods: In this cross-sectional study, 130 married women with a definite diagnosis of PCOS who were referred due to infertility were recruited. They were evaluated concerning their sexual function in the domains of desire, arousal, lubrication, orgasm, satisfaction and pain with the female sexual function index (FSFI) questionnaire.
Results: The frequency of sexual dysfunction was verified 57.7% in PCOS patients with the domains of desire and arousal being commonly affected in 99.2% and 98.5%of cases respectively. BMI had a significant effect on sexual desire and arousal (p=0.02) while the effect of hirsutism was significant on all domains (p<0.001 for total FSFI score) except for dyspareunia.
Conclusion: PCOS patients markedly suffer from sexual dysfunction as comorbidity. It seems appropriate to screen all PCOS patients for sexual function with a simple short questionnaire such as FSFI. Targeted interventions could be considered to help improve their quality of life along with other treatments. 

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