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Showing 2 results for Hamedani

Farnaz Sohrabvand, Fedyeh Haghollahi, Masoomeh Maasomi, Leila Asgarpoor, Mamak Shariat, Mahtab Hamedani,
Volume 7, Issue 4 (7-2009)
Abstract

Background: In spite of the great progress in assisted reproductive techniques ( ART), and although good quality embryos are transferred,  pregnancy rates have remained around 30%-35% due to low implantation rates.
Objective: The aim of this study was to assess and compare the effects of administrating indomethacin or hyoscine suppositories prior to embryo transfer on the pregnancy rate in ART cycles.
Materials and Methods: This double-blind clinical trial was performed in Vali-e-Asr Hospital as a pilot study from August 2005 through December 2006 on 66 infertile women in ART cycles. Controlled ovarian hyperstimulation  was done using recombinant FSH (Gonal-F) with a long GnRH analogue protocol. After obtaining written consent, the subjects were randomly allocated into three  equal groups (n=22). Groups A and B received  indomethacin and hyoscine rectal suppositories, respectively 30 minutes  before embryo transfer and group C was the control group. Data were analyzed by χ2 , t-test, ANOVA, and Kruskall Wallis tests.
Results: Overall pregnancy rate was 31% (n=21) with 13.6% (n=3) in  group A,  45.5% (n=10), and 36% (n=8) in groups B and C respectively, which shows that pregnancy rate is significantly higher in the group using hyoscine compared to  the other two groups (p=0.04). Uterine muscle cramps were experienced by 3 women (13.6%) in group C while none were reported by women in groups A or B, which shows a significant difference (p<0.04).
Conclusion: It seems that  compared to indomethacin, hyoscine administration 30 minutes prior to embryo transfer can significantly increase pregnancy rates  by reducing uterine and cervical muscle spasm.
Laaya Hamedanian, Bita Badehnoosh, Niloofar Razavi-Khorasani, Zinat Mohammadpour, Mozaffari-Khosravi Hassan ,
Volume 17, Issue 11 (November 2019)
Abstract

Background: Preeclampsia is considered as a serious life-threatening condition that could affect both maternal and fetal outcome. Many studies have examined the association of nutritional factors with the incidence of preeclampsia. However, little is known about the possible role of vitamin D in the development of preeclampsia among the Iranian population.
Objective: The aim of the present study was to evaluate the association between vitamin D status and preeclampsia.
Materials and Methods: A total of 120 pregnant women who were referred to Kamali and Alborz General Hospital located in the Karaj City were enrolled in this study and categorized into preeclamptic and control groups (n = 60/each). The clinical details of patients such as demographic characteristics and laboratory findings were obtained from the patients. The serum levels of vitamin D, calcium, phosphorus, and parathormone were also measured. Multivariate logistic regression analysis was used to assess for independent predictors of preeclampsia.
Results: The mean age among pregnant women with preeclampsia and control group were 31.48 ± 5.25 and 29.01 ± 5.28, respectively. The mean body mass index among the preeclamptic group was 27.92 ± 4.98, which was significantly higher compared to the control group (p < 0.001). The serum vitamin D levels were significantly lower in women with preeclampsia compared to the control subjects (p = 0.007). Moreover, no correlation between vitamin D deficiency and predisposing factors of preeclampsia was observed after adjusting for confounding factors.
Conclusion: Our study revealed that serum vitamin D level is significantly lower in among the pregnant women diagnosed with preeclampsia compared to the healthy subjects. However, no correlation was observed between the vitamin D status and the risk of preeclampsia development.

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