Volume 15, Issue 8 (9-2017)                   IJRM 2017, 15(8): 497-502 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Kumar N, K Singh A, R Choudhari A. Impact of age on semen parameters in male partners of infertile couples in a rural tertiary care center of central India: A cross-sectional study. IJRM. 2017; 15 (8) :497-502
URL: http://journals.ssu.ac.ir/ijrmnew/article-1-845-en.html
1- Department of Obstetrics and Gynecology, Maharishi Markandeshwar Institute of Medical Sciences and Research, Ambala, Haryana, India , drnainakumar@gmail.com
2- Department of Physiology, U.P. University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India
3- Department of Physiology, Mahatma Gandhi Institute of Medical Sciences, Sewagram, Wardha, Maharashtra, India.
Abstract:   (2197 Views)
Background: High rates of sub-fertility and adverse pregnancy outcomes were seen after age 40. In contrast to oogenesis, spermatogenesis continues in elderly men.
Objective: To retrospectively study the impact of aging on semen parameters in male partners of infertile couples in the rural area of developing country over 10 years and to find out whether aging affects male factor fertility and various semen parameters in this part of developing country.
Materials and Methods: In this cross sectional study, the laboratory semen analysis records of 1219 male partners of infertile couples of a rural tertiary care center of Central India in a 10-year period from January 2005 to December 2014 were evaluated into 5 groups based on men age: Group 1: 21-28 yr (n=57); group 2: 29-35 yr (n=450); group 3: 36-42 yr (n=532); group 4: 43-49 yr (n=165), and group 5: 50-60 yr (n=15). Evaluation of all semen parameters were done according to WHO standard criteria (1999).
Results: The analysis of semen records revealed the significant negative association of semen volume, total sperm count, sperm motility, and morphology with age. There was a significant fall in total sperm count, sperm motility, and morphology after the age of 35 yr.
Conclusion: Age has significant negative effect on semen volume, total sperm count, and sperm motility and morphology in this region of India.
Full-Text [PDF 520 kb]   (551 Downloads) |   |   Full-Text (HTML)  (88 Views)  
Type of Study: Original Article |

1. Zegers-Hochschild F, Adamson GD, de Mouzon J, Ishihara O, Mansour R, Nygren K, et al. The International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) Revised Glossary on ART Terminology, 2009. Hum Reprod 2009; 24: 2683-2687. [DOI:10.1093/humrep/dep343]
2. Aflatoonian A, Seyedhassani SM, Tabibnejad N. The epidemiological and etiological aspects of infertility in Yazd province of Iran. Iran J Reprod Med 2009; 7: 117-122.
3. WHO. WHO laboratory manual for the examination and processing of human semen. 5th Ed. Gevena, WHO; 2010.
4. Nallella KP, Sharma RK, Aziz N, Agarwal A. significance of sperm characteristics in the evaluation of male infertility. Fertil Steril 2006; 85: 629-634. [DOI:10.1016/j.fertnstert.2005.08.024]
5. Agarwal A, Anandh Prabakaran S. Oxidative stress and antioxidants in male infertility: a difficult balance. Iran J Reprod Med 2005; 3: 1-8.
6. Agarwal A, Sekhon LH. The role of antioxidant therapy in the treatment of male infertility. Hum Fertil (Camb) 2010; 13: 217-225. [DOI:10.3109/14647273.2010.532279]
7. Amann RP. The cycle of the seminiferous epithelium in humans: a need to revisit? J Androl 2008; 29: 469-487. [DOI:10.2164/jandrol.107.004655]
8. Wang C, Leung A, Sinha-Hikim AP. Reproductive aging in the male brown-Norway rat: a model for the human. Endocrinology 1993; 133: 2773-2781. [DOI:10.1210/endo.133.6.8243304]
9. Johnson L. Spermatogenesis and aging in the human. J Androl 1986; 7: 331-354. [DOI:10.1002/j.1939-4640.1986.tb00943.x]
10. Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR. Baltimore Longitudinal Study of Aging. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. J Clin Endocrinol Metab 2001; 86: 724-731. [DOI:10.1210/jcem.86.2.7219]
11. Amaral S, Ramalho-Santos J. Aging, mitochondria and male reproductive function. Curr Aging Sci 2009; 2: 165-173. [DOI:10.2174/1874609810902030165]
12. Mahmoud AM, Goemaere S, El-Garem Y, Van Pottelbergh I, Comhaire FH, Kaufman JM. Testicular volume in relation to hormonal indices of gonadal function in community-dwelling elderly men. J Clin Endocrinol Metab 2003; 88: 179-184. [DOI:10.1210/jc.2002-020408]
13. Sampson N, Untergasser G, Plas E, Berger P. The ageing male reproductive tract. J Pathol 2007; 211: 206-218. [DOI:10.1002/path.2077]
14. Cooper TG, Noonan E, von Eckardstein S, Auger J, Baker HW, Behre HM, et al. World Health Organization reference values for human semen characteristics. Hum Reprod Update 2010; 16: 231-245. [DOI:10.1093/humupd/dmp048]
15. Vigeh M, Smith DR, Hsu P-C. How does lead induce male infertility? Iran J Reprod Med 2011; 9: 1-8.
16. Brawer MK. Testosterone Replacement in Men with Andropause: An Overview. Rev Urol 2004; 6 (Suppl.): S9-S15.
17. Kovac JR, Addai J, Smith RP, Coward RM, Lamb DJ, Lipshultz LI. The effects of advanced paternal age on fertility. Asian J Androl 2013; 15: 723-728. [DOI:10.1038/aja.2013.92]
18. Eskenazi B, Wyrobek AJ, Sloter E, Kidd SA, Moore L, Young S, Moore D. The association of age and semen quality in healthy men. Hum Reprod 2003; 18: 447-454. [DOI:10.1093/humrep/deg107]
19. WHO Laboratory Manual for the Examination of Human Semen and Sperm-cervical Mucus Interaction. 4th Ed. Cambridge, Cambridge University Press; 1999: 128.
20. Joffe M, Li Z. Male and female factors in fertility. Am J Epidemiol 1994; 140: 921-929. [DOI:10.1093/oxfordjournals.aje.a117180]
21. Girsh E, Katz N, Genkin L, Girtler O, Bocker J, Bezdin S, Barr I. Male age influences oocyte-donor program results. J Assist Reprod Genet 2008; 25: 137-143. [DOI:10.1007/s10815-008-9215-4]
22. Sasano N, Ichijo S. Vascular patterns of the human testis with special reference to its senile changes. Tohoku J Exp Med 1969; 99: 269-280. [DOI:10.1620/tjem.99.269]
23. Kidd SA, Eskenazi B, Wyrobek AJ. Effects of male age on semen quality and fertility: a review of the literature. Fertil Steril 2001; 75: 237-248. [DOI:10.1016/S0015-0282(00)01679-4]
24. de la Rochebrochard E, Thonneau P. Paternal age and maternal age are risk factors for miscarriage; results of a multicentre European study. Hum Reprod 2002; 17: 1649-1656. [DOI:10.1093/humrep/17.6.1649]
25. Jung A, Schuppe HC, Schill WB. Comparison of semen quality in older and younger men attending an andrology clinic. Andrologia 2002; 34: 116-22. [DOI:10.1046/j.0303-4569.2001.00487.x]
26. Klonoff-Cohen HS, Natarajan L. The effect of advancing paternal age on pregnancy and live birth rates in couples undergoing in vitro fertilization or gamete intrafallopian transfer. Am J Obstet Gynecol 2004; 191: 507-514. [DOI:10.1016/j.ajog.2004.01.035]
27. Zhu QX, Meads C, Lu ML, Wu JQ, Zhou WJ, Gao ES. Turning point of age for semen quality: a population-based study in Chinese men. Fertil Steril 2011; 96: 572-576. [DOI:10.1016/j.fertnstert.2011.06.058]
28. de Almeida Ferreira Braga DP, Setti AS, Figueira RC, Nichi M, Martinhago CD, Iaconelli A Jr, et al. Sperm organelle morphologic abnormalities: contributing factors and effects on intracytoplasmic sperm injection cycles outcomes. Urology 2011; 78: 786-791. [DOI:10.1016/j.urology.2011.06.018]
29. Slama R, Bouyer J, Windham G, Fenster L, Werwatz A, Swan SH. Influence of paternal age on the risk of spontaneous abortion. Am J Epidemiol 2005; 161: 816-823. [DOI:10.1093/aje/kwi097]
30. Kleinhaus K, Perrin M, Friedlander Y, Paltiel O, Malaspina D, Harlap S. Paternal age and spontaneous abortion. Obstet Gynecol 2006; 108: 369-377. [DOI:10.1097/01.AOG.0000224606.26514.3a]
31. Glaser RL, Broman KW, Schulman RL, Eskenazi B, Wyrobek AJ, Jabs EW. The paternal-age effect in Apert syndrome is due, in part, to the increased frequency of mutations in sperm. Am J Hum Genet 2003; 73: 939-947. [DOI:10.1086/378419]
32. Lambert SM, Masson P, Fisch H. The male biological clock. World J Urol 2006; 24: 611-617. [DOI:10.1007/s00345-006-0130-y]
33. Wyrobek AJ, Eskenazi B, Young S, Arnheim N, Tiemann-Boege I, Jabs EW, Glaser RL, Pearson FS, Evenson D. Advancing age has differential effects on DNA damage, chromatin integrity, gene mutations, and aneuploidies in sperm. Proc Natl Acad Sci USA 2006; 103: 9601-9606. [DOI:10.1073/pnas.0506468103]
34. Schmid TE, Eskenazi B, Baumgartner A, Marchetti F, Young S, Weldon R, et al. The effects of male age on sperm DNA damage in healthy non-smokers. Hum Reprod 2007; 22: 180-187. [DOI:10.1093/humrep/del338]
35. Ford WC, North K, Taylor H, Farrow A, Hull MG, Golding J. Increasing paternal age is associated with delayed conception in a large population of fertile couples: evidence for declining fecundity in older men. The ALSPAC study team (Avon longitudinal study of pregnancy and childhood). Hum Reprod 2000; 15: 1703-1708. [DOI:10.1093/humrep/15.8.1703]
36. Mukhopadhyay D, Varghese AC, Pal M, Banerjee SK, Bhattacharyya AK, Sharma RK, et al. Semen quality and age-specific changes: a study between two decades on 3,729 male partners of couples with normal sperm count and attending an andrology laboratory for infertility-related problems in an Indian city. Fertil Steril 2010; 93: 2247-2254. [DOI:10.1016/j.fertnstert.2009.01.135]
37. Itoh N, Kayama F, Tatsuki TJ, Tsukamoto T. Have sperm counts deteriorated over the past 20 years in healthy, young Japanese men? Results from the Sapporo area. J Androl 2001; 22: 40-44.
38. Seo JT, Rha KH, Park YS, Lee MS. Semen quality over a 10-year period in 22,249 men in Korea. Int J Androl 2000; 23: 194-198. [DOI:10.1046/j.1365-2605.2000.00226.x]
39. Rolf C, Behre HM, Nieschlag E. Reproductive parameters of older compared to younger men of infertile couples. Int J Androl 1996; 19: 135-142. [DOI:10.1111/j.1365-2605.1996.tb00451.x]
40. Auger J, Kunstmann JM, Czyglik F, Jouannet P. Decline in semen quality among fertile men in Paris during the past 20 years. N Engl J Med 1995; 332: 281-285. [DOI:10.1056/NEJM199502023320501]
41. Fisch H, Goluboff ET, Olson JH, Feldshuh J, Broder SJ, Barad DH. Semen analyses in 1,283 men from the United States over a 25-year period: no decline in quality. Fertil Steril 1996; 65: 1009-1014. [DOI:10.1016/S0015-0282(16)58278-8]
42. Andolz P, Bielsa MA, Vila J. Evolution of semen quality in North-eastern Spain: a study in 22,759 infertile men over a 36 year period. Hum Reprod 1999; 14: 731-735. [DOI:10.1093/humrep/14.3.731]
43. Sloter E, Schmid TE, Marchetti F, Eskenazi B, Nath J, Wyrobek AJ. Quantitative effects of male age on sperm motion. Hum Reprod 2006; 21: 2868-2875. [DOI:10.1093/humrep/del250]
44. Gopalkrishnan K. Characteristics of semen parameters in a selected population of Indian men over a period of 10years. Curr Sci 1998; 75: 939-940.
45. Harris ID, Fronczak C, Roth L, Meacham RB. Fertility and the Aging Male. Rev Urol 2011; 13: e184-e190.
46. Sartorius GA, Nieschlag E. Paternal age and reproduction. Hum Reprod Update 2010; 16: 65-79. [DOI:10.1093/humupd/dmp027]
47. Hellstrom WJ, Overstreet JW, Sikka SC, Denne J, Ahuja S, Hoover AM, Sides GD, Cordell WH, Harrison LM, Whitaker JS. Semen and sperm reference ranges for men 45 years of age and older. J Androl 2006; 27: 421-428. [DOI:10.2164/jandrol.05156]
48. Levitas E, Lunenfeld E, Weisz N, Friger M, Potashnik G. Relationship between age and semen parameters in men with normal sperm concentration: analysis of 6022 semen samples. Andrologia 2007; 39: 45-50. [DOI:10.1111/j.1439-0272.2007.00761.x]
49. Cardona Maya W, Berdugo J, Cadavid Jaramillo A. The effects of male age on semen parameters: analysis of 1364 men attending an andrology center. Aging Male 2009; 12: 100-103. [DOI:10.3109/13685530903322841]
50. Silva LF, Oliveira JB, Petersen CG, Mauri AL, Massaro FC, Cavagna M, et al. The effects of male age on sperm analysis by motile sperm organelle morphology examination (MSOME). Reprod Biol Endocrinol 2012; 10: 19. [DOI:10.1186/1477-7827-10-19]
51. Stone BA, Alex A, Werlin LB, Marrs RP. Age thresholds for changes in semen parameters in men. Fertil Steril 2013; 100: 952-958. [DOI:10.1016/j.fertnstert.2013.05.046]
52. Purandhar K, Seshadri S. Age associated variations in human neutrophil and sperm functioning. Asian Pac J Reprod 2013; 2: 201-208. [DOI:10.1016/S2305-0500(13)60147-5]
53. Omran HM, Bakhiet M, Dashti MG. Evaluation of age effects on semen parameters of infertile males. Andrology 2013; 2: 106.
54. Priyadarsini S, Panda B, Dash C, Routray P. Effect of age and abstinence on semen quality: A retrospective study in a teaching hospital. Asian Pacific J Reproduction 2014; 3: 134-141. [DOI:10.1016/S2305-0500(14)60017-8]
55. Sengupta P, Nwagha U. The aging sperm: Is the male reproductive capacity ticking to biological extinction? J Basic Clin Reprod Sci 2014; 3: 1-7. [DOI:10.4103/2278-960X.129271]
56. Wiener-Megnazi Z, Auslender R, Dirnfeld M. Advanced paternal age and reproductive outcome. Asian J Androl 2012; 14: 69-76. [DOI:10.1038/aja.2011.69]

Send email to the article author

© 2021 CC BY-NC 4.0 | International Journal of Reproductive BioMedicine

Designed & Developed by : Yektaweb