Volume 15, Issue 5 (6-2017)                   IJRM 2017, 15(5): 273-278 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Azami M, Azadi T, Farhang S, Rahmati S, Pourtaghi K. The effects of multi mineral-vitamin D and vitamins (C+E) supplementation in the prevention of preeclampsia: An RCT. IJRM. 2017; 15 (5) :273-278
URL: http://journals.ssu.ac.ir/ijrmnew/article-1-825-en.html
1- Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran
2- Nursing and Midwifery Faculty, Ilam University of Medical Sciences, Ilam, Iran
3- Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran
4- Nursing and Midwifery Faculty, Ilam University of Medical Sciences, Ilam, Iran , kh.pourtaghi@yahoo.com
Abstract:   (3160 Views)
Background: Several studies have reported the uncertain role of multi-minerals andvitamins in the prevention of preeclampsia.
Objective: The present study aims to investigate the effect of multimineral-vitaminD supplements (calcium, magnesium, zinc and Vitamin D) and vitamins (C+ E) inthe prevention of preeclampsia.
Materials and Methods: In this randomized clinical trial, 90 pregnant women weredivided into three groups: group A received Ferrous sulfate (1 tablet/day) + onetablet of Claci-care multimineral-vitamin D containing 800mg calcium, 200mgmagnesium, 8mg zinc and 400 IU Vitamin D3 per day; group B received Ferroussulfate (1 tablet/day) + 250 mg vitamin C + 55 mg vitamin E; and the controlsreceived only one Ferrous sulfate tablet daily.
Results: The incidence of preeclampsia in group A was significantly lower than thecontrol group (p=0.03), while there was no significant difference between group Band controls (p=0.50), as well as groups A and B (p=0.063). The incidence ofneonatal complications in the group A was significantly lower than the control group(p=0.01), while there was no significant difference between group B and control(p=0.48).
Conclusion: According to the results, calcium, magnesium, and zinc supplementshave a significant effect on the prevention of preeclampsia. In addition, prescriptionof multimineral-vitamin D during pregnancy can be a low-cost and affordable wayto reduce the incidence of preeclampsia in women who are at high risk ofpreeclampsia
Full-Text [PDF 530 kb]   (425 Downloads) |   |   Full-Text (HTML)  (97 Views)  
Type of Study: Original Article |

1. Steegers EA, von Dadelszen P, Duvekot JJ, Pijnenborg R. Pre-eclampsia. Lancet 2010; 376: 631-644. [DOI:10.1016/S0140-6736(10)60279-6]
2. Aksoy Ü, Aksoy H, Açmaz G, Babayiğit M, Kandemir Ö. Umbilical artery serum chitotriosidase concentration in pregnancies complicated by preeclampsia and relationship between chitotriosidase levels and fetal blood flow velocity. Hypertens Pregnancy 2013; 32: 401-409. [DOI:10.3109/10641955.2013.810239]
3. Tayyar A, Tayyar AT, Abdülrezzak Ü, Kula M, Taş M, Tayyar M. The role of midtrimester amniotic fluid leptin and endothelin-1 levels in prediction of preeclampsia. J Turk Soc Obstet Gynecol 2012; 9: 37-41. [DOI:10.5505/tjod.2012.42204]
4. Garcia-Tizon Larroca S, Tayyar A, Poon LC, Wright D, Nicolaides KH. Competing risks model in screening for preeclampsia by biophysical and biochemical markers at 30-33 weeks' gestation. Fetal Diagn Ther 2014; 36: 9-17. [DOI:10.1159/000362518]
5. Asgharnia M, Faraji R, Mirhaghjoo N, Atrkar Roshan Z, Ashrafkhani B, Moslehi M. Survey of predictive value of 4-hour urine collection for diagnosis of proteinuria in preeclampsia. Iran J Reprod Med 2013; 11: 647-652.
6. Sibai BM. Diagnosis and management of gestational hypertension and preeclampsia. Obstet Gynecol 2003; 102: 181-92.
7. Park JE. Text book of preventive and social medicine. 1st Ed. Gillan, Medical University publication; 2002: 237-243.
8. Garovic VD, August P. Preeclampsia and the future risk of hypertension: the pregnant evidence. Curr Hypertens Rep 2013; 15: 114-121. [DOI:10.1007/s11906-013-0329-4]
9. Saghafi N, Vatanchi AM, Tara F, Pourali L, Dadgar S. Evaluation of selected thrombotic factors among pregnant women with preeclampsia and normal pregnant women. Iran J Reprod Med 2014; 12: 793-798.
10. Heidrich M-B, Wenzel D, von Kaisenberg CS, Schippert C, von Versen-Höynck FM. Preeclampsia and long-term risk of cardiovascular disease: what do obstetrician- gynecologists know? BMC Pregnancy Childbirth 2013; 13: 61. [DOI:10.1186/1471-2393-13-61]
11. Gilbert E, Harman J. Manual of high risk pregnancy and delivery. 2nd Ed. St. Louis, Mosby; 2003: 445-462.
12. Santos VM. Preeclampsia prevention: a case-control study nested in a cohort. Revista Colombia Médica 2016; 47: 67-70.
13. Kumar A, Devi SG, Batra S, Singh C, Shukla DK. Calcium supplementation for the prevention of pre-eclampsia. Int J Gynecol Obstet 2009; 104: 32-36. [DOI:10.1016/j.ijgo.2008.08.027]
14. Kanagal DV, Rajesh A, Rao K, Devi UH, Shetty H, Kumari S, et al. Levels of serum calcium and magnesium in pre-eclamptic and normal pregnancy: A study from Coastal India. J Clin Diagn Res 2014; 8: OC01-OC0. [DOI:10.7860/JCDR/2014/8872.4537]
15. Jain S, Sharma P, Kulshreshtha S, Mohan G, Singh S. The role of calcium, magnesium, and zinc in pre-eclampsia. Biol Trace Element Res 2010; 133: 162-170. [DOI:10.1007/s12011-009-8423-9]
16. Vafaei H, Dalili M, Amin Hashemi S. Serum concentration of calcium, magnesium and zinc in normotensive versus preeclampsia pregnant women: A descriptive study in women of Kerman province of Iran. Int J Reprod BioMed 2015; 13: 23-26.
17. Kim J, Kim YJ, Lee R, Moon JH, Jo I. Serum levels of zinc, calcium, and iron are associated with the risk of preeclampsia in pregnant women. Nutr Res 2012; 32: 764-769. [DOI:10.1016/j.nutres.2012.09.007]
18. Abedi P, Mohaghegh Z, Afshary P, Latifi M. The relationship of serum vitamin D with pre‐eclampsia in the Iranian women. Matern Child Nutr 2014; 10: 206-212. [DOI:10.1111/mcn.12058]
19. Spinnato JA, Freire S, e Silva JLP, Rudge MVC, Martins-Costa S, Koch MA, et al. Antioxidant therapy to prevent preeclampsia: a randomized controlled trial. Obstet Gynecol 2007; 110: 1311-1318. [DOI:10.1097/01.AOG.0000289576.43441.1f]
20. Polyzos NP, Mauri D, Tsappi M, Tzioras S, Kamposioras K, Cortinovis I, et al. Combined vitamin C and E supplementation during pregnancy for preeclampsia prevention: a systematic review. Obstet Gynecol Surv 2007; 62: 202-206 [DOI:10.1097/01.ogx.0000256787.04807.da]
21. Salles AM, Galvao TF, Silva MT, Motta LC, Pereira MG. Antioxidants for preventing preeclampsia: a systematic review. Sci World J 2012; 2012: 243476. [DOI:10.1100/2012/243476]
22. Zhang C, Williams MA, King IB, Dashow EE, Sorensen TK, Frederick IO, Thompson ML, Luthy DA. Vitamin C and the risk of preeclampsia results from dietary questionnaire and plasma assay. Epidemiology 2002; 13; 409-416. [DOI:10.1097/00001648-200207000-00008]
23. Chappell LC, Seed PT, Brilley AL, Kelly FJ, Lee R, Hunt BJ, et al. Effect of antioxidants on the occurrence of preeclampsia in women at increased risk: a randomised trial. Lancet 1999; 354: 810-816. [DOI:10.1016/S0140-6736(99)80010-5]
24. Bowen RS, Mars M, Chuturgoon AA, Dutlon MF. The response of dietary antioxidants vitamin E and vitamin C to oxidative stress in preeclampsia. J Obstet Gynecol 1998; 18: 9-13. [DOI:10.1080/01443619868172]
25. Dabirieskoei A, Mazlumzade S, Amir moghademi H, Akbar shahiO, Eskanderi M. Compare Bararleptin levels in women with preeclampsia and women with normal blood pressure Bardarba referred to Vali-e Zanjan Center. J Zanjan Univ Med Sci 2012; 77: 70-77.
26. O'Brien TE, Ray JG, Chan WS. Maternal body mass index and the risk of preeclampsia: a systematic overview. Epidemiology 2003; 14: 368-374. [DOI:10.1097/01.EDE.0000059921.71494.D1]
27. Asemi Z, Razavi BS, Ebrahimi Z, Baniahmadi Z, Salehi S, Nazemi F, et al. A randomized controlled clinical trial evaluating the effect of multi mineral-vitamin D supplementation on pregnancy outcomes in pregnant women at risk for pre-eclampsia. FEYZ 2013; 16: 765-766.
28. Robinson CJ, Wagner CL, Hollis BW, Baatz JE. Maternal vitamin D and fetal growth in early-onset severe preeclampsia. Am J Obstet Gynecol 2011; 204: 556. [DOI:10.1016/j.ajog.2011.03.022]
29. Ghomian N, Lotfalizade M, Mohedian A. A comparative study of serum levels of vitamin D in women with severe preeclampsia and healthy pregnant women. J Obstet Gynecol Infertil 2015; 18: 1-6.
30. Rumbold A, Duely L, Crowther CA, Haslam RR. Antioxidants for preventing preeclampsia. Cochrane Database Syst Rev 2008; 23: CD004227.
31. Rumbold AR, Crowther CA. Haslam RR, Dekker GA, Robinson JS. Vitamin C and E and the risks of preeclampsia and perinatal complications. N Engl J Med 2006; 354: 1796-1806. [DOI:10.1056/NEJMoa054186]
32. Rahmanian M, Aghayan SH, GHorbani R. The effect of combined administration of vitamin E and C in the prevention of soil Lampsy blades and some pregnancy outcomes in nulliparous pregnant women. J Obstet Gynecol Infertil 2011; 14: 22-27

Send email to the article author

© 2021 All Rights Reserved | International Journal of Reproductive BioMedicine

Designed & Developed by : Yektaweb