Volume 13, Issue 11 (12-2015)                   IJRM 2015, 13(11): 687-696 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Mojibian M, Soheilykhah S, Fallah Zadeh M A, Jannati Moghadam M. The effects of vitamin D supplementation on maternal and neonatal outcome: A randomized clinical trial. IJRM. 2015; 13 (11) :687-696
URL: http://journals.ssu.ac.ir/ijrmnew/article-1-606-en.html
1- Department of Obstetrics and Gynecology, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2- Department of Endocrine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran , s_soheilykhah@yahoo.com
3- Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4- Department of Obstetrics and Gynecology, Mojibian Hospital, Yazd, Iran
Abstract:   (3521 Views)
Background: Vitamin D supplementation during pregnancy has been supposed to defend against adverse gestational outcomes. Objective: This randomized clinical trial study was conducted to assess the effects of 50,000 IU of vitamin D every two weeks supplementation on the incidence of gestational diabetes (GDM), gestational hypertension, preeclampsia and preterm labor, vitamin D status at term and neonatal outcomes contrasted with pregnant women that received 400 IU vitamin D daily. Materials and Methods: 500 women with gestational age 12-16 weeks and serum 25 hydroxy vitamin D (25 (OH) D ) less than 30 ng/ml randomly categorized in two groups. Group A received 400 IU vitamin D daily and group B 50,000 IU vitamin D every 2 weeks orally until delivery. Maternal and Neonatal outcomes were assessed in two groups. Results: The incidence of GDM in group B was significantly lower than group A (6.7% versus 13.4%) and odds ratio (95% Confidence interval) was 0.46 (0.24-0.87) (P=0.01). The mean ± SD level of 25 (OH) D at the time of delivery in mothers in group B was significantly higher than A (37.9 ± 19.8 versus 27.2 ± 18.8 ng/ml, respectively) (P=0.001). There were no differences in the incidence of preeclampsia, gestational hypertension, preterm labor, and low birth weight between two groups. The mean level of 25 (OH) D in cord blood of group B was significantly higher than group A (37.9 ± 18 versus 29.7 ± 19ng/ml, respectively). Anthropometric measures between neonates were not significantly different. Conclusion: Our study showed 50,000 IU vitamin D every 2 weeks decreased the incidence of GDM.
Full-Text [PDF 687 kb]   (289 Downloads) |   |   Full-Text (HTML)  (81 Views)  
Type of Study: Original Article |

1. Kaludjerovic J, Vieth R. Relationship between vitamin D during perinatal development and health. J Midwifery Womens Health 2010; 55: 550-560. [DOI:10.1016/j.jmwh.2010.02.016]
2. De-Regil L M, Palacios C, Ansary A, Kulier R, Pena-Rosas JP. Vitamin D supplementation for women during pregnancy. Cochrane Database Syst Rev 2012; 2: CD008873. [DOI:10.1002/14651858.CD008873.pub2]
3. Ross AC, Taylor CL, Yaktine AL, Del Valle HB. Dietary reference intakes for calcium and vitamin D. Washington (DC); National Academy Press; 2011.
4. Hollis BW, Wagner CL. Assessment of dietary vitamin D requirements during pregnancy and lactation. Am J Clin Nutr 2004; 79: 717–726.
5. Vieth R, Chan PC, MacFarlane GD. Efficiency and safety of vitamin D3 intake exceeding the lowest observed adverse effect level (LOAEL). Am J Clin Nutr 2001; 73: 288–294.
6. Heaney RP, Davies KM, Chen TC, Holick MF, Barger-Lux MJ. Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr 2003; 77: 204-210. [DOI:10.1093/ajcn/77.1.204]
7. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011; 96: 1911–1930. [DOI:10.1210/jc.2011-0385]
8. Hollis BW, Johnson D, Hulsey TC, Ebeling M, Wagner CL. Vitamin D supplementation during pregnancy: double blind, randomized clinical trial of safety and effectiveness. J Bone Miner Res 2011; 26: 2341–2357. [DOI:10.1002/jbmr.463]
9. Clifton-Bligh RJ, McElduff P, McElduff A. Maternal vitamin D deficiency, ethnicity and gestational diabetes. Diabet Med 2008; 25: 678-684. [DOI:10.1111/j.1464-5491.2008.02422.x]
10. Lau SL, Gunton JE, Athayde NP, Byth K, Cheung NW. Serum 25 hydroxyvitamin D and glycated haemoglobin levels in women with gestational diabetes. Med J Aust 2011; 194: 334-337.
11. Soheilykhah S, Mojibian M, Rashidi M, Rahimi-Saghand S, Jafari F. Maternal Vitamin D Status in Gestational Diabetes Mellitus. Nutr Clin Pract 2010; 25: 524-527. [DOI:10.1177/0884533610379851]
12. Maghbooli Z, Hossein-Nezhad A, Karimi F, Shafaei AR, Larijani B. Correlation between vitamin D3 deficiency and insulin resistance in pregnancy. Diabetes Metab Res Rev 2008; 24: 27-32. [DOI:10.1002/dmrr.737]
13. Soheilykhah S, Mojibian M, Moghadam MJ, Shojaoddiny-Ardekani A. The effect of different doses of vitamin D supplementation on insulin resistance during pregnancy. Gynecol Endocrinol 2013; 29: 396-399. [DOI:10.3109/09513590.2012.752456]
14. American Diabetes Association. Gestational diabetes mellitus. Diabetes Care 2004; 27: 88–90. [DOI:10.2337/diacare.27.2007.S88]
15. Zhang C, Qiu C, Hu FB, David RM, Van Dam RM, Bralley A, et al. Maternal plasma 25-hydroxyvitamin D concentrations and the risk for gestational diabetes mellitus. PLoS One 2008; 3: e3753. [DOI:10.1371/journal.pone.0003753]
16. Makgoba M, Nelson SM, Savvidou M, Messow CM, Nicolaides K, Sattar N. First-trimester circulating 25-hydroxyvitamin D levels and development of gestational diabetes mellitus. Diabetes Care 2011; 34: 1091-1093. [DOI:10.2337/dc10-2264]
17. Parlea L, Bromberg IL, Feig DS, Vieth R, Merman E, Lipscombe LL. Association between serum 25-hydroxyvitamin D in early pregnancy and risk of gestational diabetes mellitus. Diabet Med 2012; 29: e25-32. [DOI:10.1111/j.1464-5491.2011.03550.x]
18. Poel YH, Hummel P, Lips P, Stam F, Van der Ploeg T, Simsek S. Vitamin D and gestational diabetes:a systematic review and meta-analysis. Eur J Inter Med 2012; 23: 465-469. [DOI:10.1016/j.ejim.2012.01.007]
19. Aghajafari F, Nagulesapillai T, Ronksley P, Tough S C, O’Berine M, Rabi DM. Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: Systematic review and meta-analysis of observational studies. BMJ 2013; 346: f1169. [DOI:10.1136/bmj.f1169]
20. Yap C, Cheung NW, Gunton JE, Athayde N, Munns CF, Duke A, et al. Vitamin D Supplementation and the Effects on Glucose Metabolism During Pregnancy: A Randomized Controlled Trial. Diabetes Care 2014; 37: 1837-1844. [DOI:10.2337/dc14-0155]
21. Hossain N, Kanani FH, Ramzan R, Kausar R, Ayaz S, Khanani R, et al. Obstetric and neonatal outcomes of maternal vitamin D supplementation: results of an open-label, randomized controlled trial of antenatal vitamin D. Pakistani women J Clin Endocrinol Metab 2014; 99: 2448-2455. [DOI:10.1210/jc.2013-3491]
22. Asemi Z, Samimi M, Tabassi Z, Sabahi SS, Esmaillzadeh A. A randomized controlled clinical trial investigating the effect of DASH diet on insulin resistance, inflammation, and oxidative stress in gestational diabetes. Nutrition 2013; 29: 619-624. [DOI:10.1016/j.nut.2012.11.020]
23. Norman AW, Frankel JB, Heldt AM, Grodsky GM. Vitamin D deficiency inhibits pancreatic secretion of insulin. Science 1980; 209: 823–825. [DOI:10.1126/science.6250216]
24. Harvey NC, Javaid MK, Poole JR, Taylor P, Robinson SM, Inskip HM, et al. Paternal skeletal size predicts intrauterine bone mineral accrual. J Clin Endocrinol Metab 2008; 93: 1676–1681. [DOI:10.1210/jc.2007-0279]
25. Javaid MK, Crozier SR, Harvey NC, Gale CR, Dennison EM, Boucher BJ, et al. Maternal vitamin D statusduring pregnancy and childhood bone mass at age 9 years: a longitudinal study. Lancet 2006; 367: 36–43. [DOI:10.1016/S0140-6736(06)67922-1]
26. Mahoon P, Harvey N, Crozier S, Inskip H, Robinson S, Arden N, et al. Low maternal vitamin D status and fetal bone development: cohort study. J Bone Miner Res 2010; 25: 14-19. [DOI:10.1359/jbmr.090701]
27. Brooke OG, Brown IR, Bone CD, Carter ND, Cleeve HJ, Maxwell JD, et al. Vitamin D supplements in pregnant Asian women: effects on calcium status and fetal growth. Br Med J 1980; 280: 751-754. [DOI:10.1136/bmj.280.6216.751]
28. Marya RK, Rathee S, Dua V, Sangwan K. Effect of vitamin D supplementation durin pregnancy on fetal growth. Indian J Med Res 1988; 88: 488-492.
29. Delvin EE, Salle BL, Glorieux FH, Adeleine P, David LS. Vitamin D supplementation during pregnancy: effect on neonatal calcium homeostasis. J Pediatr 1986; 109: 328–334. [DOI:10.1016/S0022-3476(86)80396-1]
30. Mallet E, Gugi B, Brunelle P, Henocq A, Basuyau JP, Lemeur H. Vitamin D supplementation inpregnancy: a controlled trial of two methods. Obstet Gynecol 1986; 68: 300–304. [DOI:10.1097/00006250-198609000-00002]
31. Maghbooli Z, Hossein–Nezhad A, Shafaei AR, Karimi F, Madani FS, Larijani B. Vitamin D status in mothers and their newborns in Iran. BMC Pregnnancy and childbirth 2007; 7: 1. [DOI:10.1186/1471-2393-7-1]
32. Sabour H, Hossein-Nezhad A, Maghbooli Z, Madani F, Mir E, Larijani B. Relationship between pregnancy outcomes and maternal vitamin D and calcium intake: A cross-sectional study. Gynecol Endocrinol 2006; 22: 585-589. [DOI:10.1080/09513590601005409]
33. Sablok A, Batra A, Thariani K, Batra A, Bharti R, Aggrawal AR, et al. Supplementation of vitamin D in pregnancy and its correlation with feto-maternal outcome. Clinic Endocrinol 2015; 83: 536-541. [DOI:10.1111/cen.12751]
34. Fernandez-Alonso AM, Dionis-Sanchez EC, Chedraui P, Gonzalez-Salmeron MD, Perez-Lopez FR. First-trimester maternal serum 25-hydroxyvitamin D (3) status and pregnancy outcome. Int J Gynaecol Obstet 2012; 116: 6–9. [DOI:10.1016/j.ijgo.2011.07.029]
35. YU CKH, Sykes L, Sethit M, TeohTG, Robinson S. Vitamin D deficiency and supplementation during pregnancy. Clin Endocrinol 2009; 70: 685-690. [DOI:10.1111/j.1365-2265.2008.03403.x]
36. Bondar LM, Catov JM, Zumda JM, Cooper ME, Parrot D, Roerts JM. Maternal serum 25-hydroxyvitamin D concentrations are associated with small-for- gestational age births in white women. J Nutr 2010; 140: 999-1006. [DOI:10.3945/jn.109.119636]
37. Morley R, Carlin JB, Pasco JA, Wark JD. Maternal 25-hydroxyvitamin D and parathyroid hormone concentration and offspring birth size. J Clin Endocrinol Metab 2006; 91: 906-912. [DOI:10.1210/jc.2005-1479]
38. Mahon P, Harvey N, Crozier S, Inskip H, Robinson S, Arden N, et al. Low maternal vitamin D status and fetal bone development: cohort study. J Bone Miner Res 2010; 25: 14-19. [DOI:10.1359/jbmr.090701]
39. Burris HH, Rifas-Shiman SL, Camargo CA Jr, Litonjua AA, Huh SY, Rich-Edwards JW, et al. Plasma 25-hydroxyvitamin D during pregnancy and small-for-gestational age in black and white infants. Ann Epidemiol 2012; 22: 581-586. [DOI:10.1016/j.annepidem.2012.04.015]

Send email to the article author

© 2021 All Rights Reserved | International Journal of Reproductive BioMedicine

Designed & Developed by : Yektaweb