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Showing 9 results for Zamani

Valli A Dehghani, Mohammad A Khalili, Nahid Zamani, Fakhri Dreh-Zereshki,
Volume 2, Issue 1 (7-2004)

Proper collections of human ejaculates are necessary for semen analysis and infertility treatment purposes. The objective of this study was to assess the seminal characteristics of ejaculates collected by patients via masturbation and coitus interruptus. Thirty individuals produced one sample via masturbation and one via incomplete coitus during a 3-days interval. The semen parameters were compared and analyzed with student t-test and Nemar test. The results showed that mean values for progressive motility of spermatozoa were increased from 46.81+15.7% to 58.76+13.5% in coitus interruptus and masturbation, respectively (P<0.01). Also, the mean values for normal sperm morphology was 54.03+25.1% in coitus interruptus and 63.36+13.4% in samples collected via masturbation (P<0.01). In addition, sperm concentration was significantly improved in ejaculates collected with masturbation (P<0.05). Although, insignificant, the concentration of round cells were lower in specimens collected via masturbation than coitus interruptus. Therefore, via masturbation method, better semen characteristics were yielded which subsequently may improve the infertility treatment outcome.
Mohammad Ehsan Rahiminejad, Amirhossein Moaddab, Mehrnoosh Ebrahimi, Soghra Rabiee, Alireza Zamani, Mohammad Ezzati, Alireza Abdollah Shamshirsaz,
Volume 13, Issue 9 (10-2015)

Background: Endometrial secretion analysis is a non-invasive and promising method in evaluation of endometrial receptivity.
Objective: The aim of the present study was to assess the relationship between the success rate of IVF procedures and some endometrial secretion cytokines, including interleukin-1β (IL-1β), tumor necrosis factor (TNF-α), interferon gamma-induced protein 10 (IP-10), and monocyte chemoattractant protein (MCP).
Materials and Methods: In a prospective cohort study, 50 women selected for IVF met the study inclusion criteria. All the patients underwent endometrial secretion aspiration prior to embryo transfer. The level of IL-1β, TNF-α, IP-10 and MCP were analyzed by enzyme-linked immunosorbent assay method using special standard kits. To detect successful implantation and pregnancy patients underwent serum human chorionic gonadotropin measurements and ultrasound evaluation.
Results: Five samples were excluded. Nine women (20%) had successful clinical pregnancies, which resulted in live birth. Other 36 women (80%) were classified as failed pregnancy. Comparison of cytokine levels showed lower concentrations of TNF-α, IP-10, and MCP in the group with successful clinical pregnancy compared to the group with failed pregnancy (p=0.007, 0.005 and 0.001, respectively). However, no significant difference was revealed in IL-1β levels between two groups (p=0.614).
Conclusion: The current study suggested that lower concentrations of TNF-α, IP-10, and MCP in endometrial secretions might be associated with improved endometrial receptivity and IVF outcome. Regarding IL-1β, no statistically significant differences were seen between the groups with and without successful pregnancy.
Anahita Khodabakhshi Koolaee, Mahnaz Zamani, Leili Moslanejad, Safieh Jamali,
Volume 14, Issue 1 (1-2016)

Pregnancy and childbirth, as a part of the triple crises of life, such as puberty and marriage, are of considerable importance and could be matter of research. Like every other crisis, pregnancy is consisted of both physical and psychological changes. Besides, assisting in improvement of maternal health helps to understand these changes and their interactions, which create different clinical presentations in different people (1, 2). There are rare studies regarding the satisfaction of life and sexual function in these individuals. Health care for mothers during pregnancy and prevention of fears, anxiety, and stress are essential issues. Moreover, following pregnancy, sanitation rules are the most important social requirements that include the following items: A) providing sanitary conditions during pregnancy with minimum physical and mental discomfort and maximum satisfaction and pleasure. B) delivery in the best possible position, having a healthy baby. C) providing the health of pregnant woman and guidelines for creating balance after childbirth (3). In general, women with unwanted pregnancy have reported lower level of all dimensions of sexual function, like; sexual stimulation, orgasm, and satisfaction. Thus, it is confirmed that there is a significant difference in sexual function between women with intended pregnancy and those with unintended pregnancy in just two sub-scales that aforementioned above. There are several reasons that changes in sexual function occur during pregnancy, both in women with intended pregnancy, and those with unintended pregnancy (4). There are certain critical stages in the life of every person that have a profound impact on the lives of individuals, including pregnancy that is one of the important periods of life. Because pregnancy for a woman looks like achieving sense of wholeness, perfection satisfies reproduction and the sense of being eternal. Although, it is an exceptional success in normal conditions, it makes the woman feeling happiness and satisfaction. So, she faces with many physical and behavioral changes (5). The lower quality of the relationship between husband and wife in the family and lack of attachment to the family and generally disorders in marital relationship can bring resentment and hatred about pregnancy. On the other hand, sexual relationship in pregnancy period alters due to the numerous physical and psychological changes. In other words, the roles of men and women turn into those of the mothers and the fathers (6). Unintended pregnancy refers to pregnancies happen without desire or intention of couples or without preplanning. When faced with an unintended pregnancy, many of the women attempt to take irrational actions. They take care of themselves less than they used to and they are likely to take actions to terminate pregnancy (7). Generally, unintended pregnancies occur for two reasons: non-use of contraceptives due to various personal and cultural reasons and the absence of fully effective contraceptive methods. According to one study, the women with unintended pregnancies suffer from lower psychological and physical recovery rates compared to women with intended pregnancies (8). Due to the nature of their pregnancies, mothers with unintended pregnancy face with numerous risks during pregnancy such as: delay, decrease or failure in admitting the authorized centers to receive sanitary cares of pregnancy period (use of folic acid, iron, diagnosis and treatment of chronic diseases, diagnosis and treatment of eclampsia), also mothers with unintended pregnancy increasing physical and sexual violence against them (9). The woman with intended pregnancy has long been waited for pregnancy and is happy and satisfied with her pregnancy. She prepares herself to be a mother and establishes an emotional relationship with her baby and gives special attention to the essential points that every pregnant woman should know and tries to accept her pregnancy and changes in family and social roles (10). Some studies have stated that women with unwanted pregnancy report higher physical and sexual abuse among their pregnancy and they decided to terminate their pregnancy. In addition, unintended pregnancy sometimes along with some strongly experience of Post-traumatic stress disorder (PTSD, symptoms of anxiety and depression. This associated symptoms impact the life satisfaction in unintended pregnancy (11). The results demonstrate a clear relationship between a woman's experience of physical violence from her husband and her ability to achieve her fertility intentions. Also there is a relationship between unintended pregnancies and domestic violence. Couples with unplanned pregnancies experience higher levels of sexual function problem before the birth of child. Couples with planned pregnancies have reported lower sexual problems during the pregnancy. While some researchers, as mentioned before, indicated the lower sexual functions in all sub-scales and general scores in women with unintended pregnancies than the women with planned pregnancies, but our results in this study was inconsistent with those findings. The women with unintended pregnancies reported lower sexual function in two scales than the women with intended pregnancy. In addition, there were differences in the life satisfaction in women with unintended pregnancies
Negar Ghazi, Mohammad Arjmand, Ziba Akbari, Ali Owsat Mellati, Hamid Saheb-Kashaf, Zahra Zamani,
Volume 14, Issue 1 (1-2016)

Background: So far, non-invasive diagnostic approaches such as ultrasound, magnetic resonance imaging, or blood tests do not have sufficient diagnostic power for endometriosis disease. Lack of a non-invasive diagnostic test contributes to the long delay between onset of symptoms and diagnosis of endometriosis.
Objective: The present study focuses on the identification of predictive biomarkers in serum by pattern recognition techniques and uses partial least square discriminant analysis, multi-layer feed forward artificial neural networks (ANNs) and quadratic discriminant analysis (QDA) modeling tools for the early diagnosis of endometriosis in a minimally invasive manner by 1H- NMR based metabolomics.
Materials and Methods: This prospective cohort study was done in Pasteur Institute, Iran in June 2013. Serum samples of 31 infertile women with endometriosis (stage II and III) who confirmed by diagnostic laparoscopy and 15 normal women were collected and analyzed by nuclear magnetic resonance spectroscopy. The model was built by using partial least square discriminant analysis, QDA, and ANNs to determine classifier metabolites for early prediction risk of disease.
Results: The levels of 2- methoxyestron, 2-methoxy estradiol, dehydroepiandrostion androstendione, aldosterone, and deoxy corticosterone were enhanced significantly in infertile group. While cholesterol and primary bile acids levels were decreased. QDA model showed significant difference between two study groups. Positive and negative predict value levels obtained about 71% and 78%, respectively. ANNs provided also criteria for detection of endometriosis.
Conclusion: The QDA and ANNs modeling can be used as computational tools in noninvasive diagnose of endometriosis. However, the model designed by QDA methods is more efficient compared to ANNs in diagnosis of endometriosis patients.
Saghar Salehpour, Marzieh Zamaniyan, Nasrin Saharkhiz, Shahrzad Zadeh Modares, Sedighe Hosieni, Samira Seif, Narges Malih, Parinaz Rezapoor, Mohammad-Reza Sohrabi,
Volume 14, Issue 9 (9-2016)

Background: Recurrent implantation failure is one of the most issues in IVF cycles.Some researchers found that beneficial effects of endometrial Scratching in womenwith recurrent implantation failure, while some authors demonstrated contrary results
Objective: The present study aimed to investigate the effect of intrauterine. Salineinfusion as a form of endometrial injury, during fresh in vitro fertilization-embryotransfer cycle, among patients with recurrent implantation failure.
Materials and Methods: In this clinical trial study 63 women undergoing assistedreproductive technology were divided into two groups either local endometrialinjury by intrauterine saline infusion during day 3-5 of the ongoing controlledovarian stimulation cycle, or IVF protocol performed without any other interventionin Taleghani Hospital, Tehran, Iran. The main outcome measure was clinicalpregnancy rates.
Results: Patients who received intra uterine saline infusion (n=20), had significantlylower clinical pregnancy numbers (1 vs. 9, p<0.05) and implantation rates (4.7% vs.41.6%, p<0.05), compared to controls (n=39). However, there was no significantdifference in miscarriage rates (9.4% vs. 8.7%, p>0.05) and multiple pregnancynumbers (1 vs. 3, p>0.05) between groups.
Conclusion: When intrauterine saline infusion as a form of endometrial injury isperformed during the ongoing IVF cycles it has negative effect on reproductiveoutcomes among patients with recurrent implantation failure.
Mahin Jamshidi Makiani, Sara Minaeian, Soheila Amini Moghaddam, Seyed Akbar Moosavi, Zahra Moeini, Vajihe Zamani, Mahnaz Karbalaei Sabbagh, Hosein Forghani,
Volume 15, Issue 5 (6-2017)

Background: Human papilloma virus (HPV) is one of the major public healthproblems and the main causes of cervical cancer. The prevalence HPV infection indeveloping countries with low financial resources is high.
Objective: This study aimed to determine the relative frequency of HPV genotypesand its sociodemographic characteristics in women referred to a general hospital inTehran, Iran from 2014-2015.
Materials and Methods: This cross-sectional study was performed in 400 womenwith Pap smear samples, referring to to a general hospital in Tehran, Iran from 2014-2015. The detection of 28 HPV genotypes was performed by using the MultiplexPCR technique. The sociodemographic survey was conducted for each HPV positivewoman.
Results: HPV-positive infection was detected in 155 (38.75%) women aged 17-85years. HPV 16 (19.1%) was the most prevalent type, followed by HPV 39 (12.5%)and HPV 18 (8.9%). The highest rate of HPV infection was observed at the age of36 years (7.7%). The level of education and economic situation of each woman wereshowed most of HPV-positive women had a high school diploma (34.6%) andaverage economic situation (67,9%). 60.9% of these women were a housewife, and67.3% lived in the capital .
Conclusion: Determination of HPV genotype and risk factor related to HPVinfection in each geographical region can lead to the production of effectivevaccines against the HPV virus. It can also be useful for disease management andhigh sensitivity diagnosis of cervical intraepithelial neoplasia.
Robabeh Taheripanah, Marzieh Zamaniyan, Atefeh Moridi, Anahita Taheripanah, Narges Malih,
Volume 15, Issue 6 (7-2017)

Background: The purpose of triggering in ovulation induction is to induce the final maturation of oocytes and their release from the ovary for fertilization.
Objective: The aim of the present study was to compare the effectiveness of gonadotropin-releasing hormone (GnRH) agonist and human chorionic gonadotropin (HCG) on the final maturation of oocytes and pregnancy rates in intrauterine insemination (IUI) cycles.
Materials and Methods: In this randomized clinical trial, 110 infertile women who were selected for IUI entered the study. Ovulation induction was performed. Group I received 0.1 mg GnRH agonist as triggering and group II received 10,000 IU of HCG. The serum Estradiol (E2), Luteinizing Hormone (LH), and Follicle-Stimulating Hormone (FSH) levels were measured at 12 and 36 hr after injection.
Results: LH surge was detected in all patients. LH levels at 12 and 36 hr after triggering was higher in Group I and it washed out earlier than group II (p=0.00). The pregnancy rate was higher in Group I, but the difference was not statistically significant (26.9% vs. 20.8%, respectively p=0.46). Also, the incidence of ovarian hyperstimulation syndrome was not different between the two groups (p=0.11). There was a significant difference regarding the estradiol levels at 36 hours after triggering (p=0.00).
Conclusion: Effects of GnRH on endogenous LH surge is sufficient for oocyte releasing and final follicular maturation. Pregnancy rates and ovarian hyperstimulation syndrome incidence were not different between the groups. We suggest that GnRH agonists might be used as an alternative option instead of HCG in IUI cycles.
Tayebeh Ghiasvand, Mohammad Taghi Goodarzi, Gholamreza Shafiee, Alireza Zamani, Jamshid Karimi, Marzieh Ghorbani, Iraj Amiri,
Volume 16, Issue 2 (February 2018)

Background: Neopterin is a significant and sensitive marker in estimating the activity of cellular immune system. Oxidative stress plays a role in the etiology of male infertility. Increased reactive oxygen species is accompanied with increase in neopterin level. Hence neopterin may be involved in male infertility.
Objective: The objective of this case-control study was to determine neopterin level in idiopathic infertile and normospermic men; furthermore, to identify its relationship with oxidative stress markers including total oxidant, malondialdehyde, sperm DNA fragmentation, and total antioxidant capacity of seminal plasma.
Materials and Methods: Forty seven infertile and forty three normospermic males were selected according to WHO criteria. Their semen and blood samples were taken; subsequently, the levels of neopterin, total oxidant, total antioxidant, malondialdehyde, and sperm DNA fragmentation were measured.
Results: The levels of neopterin, total oxidant, and malondialdehyde in seminal plasma of infertile males were significantly higher than those of normospermic group (p=0.038, 0.018, and 0.028, respectively). Furthermore, sperm DNA fragmentation in infertile men was higher than that of control group (p<0.001). Moreover, total antioxidant capacity of seminal plasma in infertile males was significantly lower than that of normospermic subjects (p=0.002). No significant difference was observed in serum neopterin, total oxidant, and malondialdehyde between the infertile and normospermic groups.
Conclusion: The significant inverse correlation between seminal plasma neopterin and total antioxidant in the infertile males supports a possible role of neopterin in male infertility. Neopterin can be suggested as a marker in monitoring and diagnosis of idiopathic male infertility.
Maryam Zamani, Robab Latifnejad Roudsari, Maryam Moradi, Habibollah Esmaily,
Volume 17, Issue 1 (January 2019 2019)

Background: Many couples experience decreasing sexual satisfaction in postpartum period. Various sexual health counseling approaches have been designed for postpartum women to address their common sexual concerns and problems.
Objective: This study aimed to investigate the effectiveness of Women’s Postpartum Sexual Health Program (WPSHP) on women’s sexual satisfaction in postpartum period.
Materials and Methods: The study was a single blind randomized clinical trial on 75 postpartum women aged 18–35 yr with low sexual satisfaction who attended urban health-care centres in Mashhad, Iran in 2016. Data were collected using a demographic questionnaire, the Depression Anxiety Stress Scales-21, and the Larson Sexual Satisfaction Questionnaire. The intervention group received counselling based on the WPSHP, a four-session, group- and couples-based program. The control group  just received postpartum routine care.
Results: Both the intervention and control groups were homogeneous for demographic variables. According to the Mann-Whitney test, sexual satisfaction score in the  intervention group was significantly higher than the control group 8 weeks after the intervention (p < 0.001). According to the Wilcoxon test, there was a significant difference in the mean score of sexual satisfaction before and after intervention in the intervention group (p < 0.001).
Conclusion: WPSHP caused higher levels of sexual satisfaction. It is therefore recommended to use this program in women during the postpartum period to promote their sexual satisfaction.

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