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Showing 4 results for Saeidi

Afsaneh Khademi, Leili Safdarian, Ashraf Alleyassin, Marzieh Agha-Hosseini, Ehsan Akbari Hamed, Hojatollah Saeidi Saeidabadi, Omid Pooyan,
Volume 2, Issue 2 (7-2004)
Abstract

Background: The etiologic cause in near one third of male factor infertility is unknown. The percentage of men with idiopathic infertility who have been successfully treated by the empirical therapeutic modalities is not high. Objective: The aim of this study was to assay the effect of L-carnitine on sperm parameters in patients who needs intracytoplasmic sperm injection (ICSI) as a method for infertility treatment. Materials and Methods: The study population consisted of 65 men (mean age± SD: 34.4 ± 6.07) presenting with primary infertility due to idiopathic oligoasthenoteratozoospermia. L-carnitine was prescribed 1gram orally every 8 hours for 3 months. Before and after the ending of the L-carnitine treatment, semen analysis was performed. Results: The proportion of patients who had motile and grade C sperms rose significantly after treatment. Percentile of abnormal shaped sperms decreased significantly after treatment. In approximately 22%, complete asthenozoospermia changed to relative asthenozoospermia. Conclusion: Appearing motile sperms will potentially improve the technique of ICSI. The magnitude of the elevation in normal morphology is not clinically obvious, but it seems that it can be important in obtaining normal-shaped sperms for intracytoplasmic injection. Designing a study on selected patients with complete asthenozoospermia who have not other abnormalities in semen parameters can reveal the real effect of carnitine therapy in this category. Article
Payam Sasannejad, Ali Mellat Ardekani, Arash Velayati, Ali Shoeibi, Morteza Saeidi, Mohsen Foroughipour, Mahmoud Reza Azarpazhooh,
Volume 10, Issue 6 (4-2012)
Abstract

Background: Muslim women tend to postpone their menstrual period using short course oral contraceptives (OC) during Ramadan, Muslims fasting month. Recently, many cases of stroke, particularly cerebral vein thrombosis (CVT), have been reported in Ramadan.
Objective: This work studies the incidence of CVT and its relation to Ramadan.
Materials and Methods: This is a cohort study conducted from October 2006 to October 2009 and included 4 consecutive Ramadan’s. All patients with definite diagnosis of CVT who were referred to the neurology department of Ghaem Hospital, Mashhad, Iran in this four-year period were included in the study.
Results: During the study period, 70 cases with CVT (11 males and 59 females) were recruited. Twenty five cases were admitted during Ramadan months which was significantly higher than all the other 32 months (p=1.9×10-7). The higher frequency of females (6 times more) among CVT cases probed by investigating possible risk factors and short term OC consumption was revealed as the major risk factor (p=0.00071).
Conclusion: Higher incidence of CVT in females during Ramadan suggests the presence of specific risk factors in this group. Our study revealed that short-term use of OCs may be a major risk factor for CVT.
Farnaz Shapouri, Shaghayegh Saeidi, Sara Ashrafi Kakhki, Omid Pouyan, Elham Amirchaghmaghi, Reza Aflatoonian,
Volume 11, Issue 11 (12-2013)
Abstract

Background: It has been suggested that malfunction of immune system may cause testicular cancer. Recently, our understanding of innate immune system has been expanded, by discovery of “Toll- like receptors” (TLRs). Some studies have shown that polymorphisms of TLR2 and 4 can effect on the risk of cancer. Also, the role of TLRs 3and 9 have been shown in apoptosis of cancer cells and metastasis in animal models.
Objective: Little information is available about the influence of innate immunity on testicular malignancy. Therefore, expression of TLRs 2, 3, 4 and 9 as main components of innate immunity has been investigated in this study.
Materials and Methods: In this case control study, TLRs gene expression was examined by RT-PCR in normal testis and testicular cancer tissues. Real time quantitative PCR (Q-PCR) analysis was used to compare the relative expression of TLRs between the samples.
Results: mRNAs of TLR 2, 3, 4 and 9 were expressed in all normal and cancer samples. Q-PCR reveals that cancer samples had stronger expression of these genes in compared with normal ones.
Conclusion: It seems that the different TLRs expression in testicular cancer cells may contribute to extensive signaling pathways involved in carcinogenesis.
Elaheh Mesdaghi-Nia, Mitra Behrashi, Arezoo Saeidi, Masoomeh Abedzadeh Kalahroodi,
Volume 14, Issue 6 (6-2016)
Abstract

Background: Measuring of maternal serum pregnancy-associated plasma protein-A (PAPP-A) in first trimester can be a way for early detection of adverse prenatal outcome due to faulty placenta.
Objective: The aim was to Determination of association between placental thickness in second trimester with low level of PAPP-A in first trimester.
Materials and Methods: In this cohort study, serum PAPP-A of 187 pregnant women was measured in the first trimester of pregnancy. Patients who had PAPP-A ≤0.8 MOM were in exposed and others who had PAPP-A >0.8 defined as unexposed group. The criteria of placental thickness in ultrasound study was thickness of 4 cm or more than 50% of placental length.
Results: Of 187 patients, 87 patients had PAPP-A >0.8 and 93 patients had PAPP-A ≤0.8. Women with low levels of PAPP-A in the first trimester, had an increased incidence placental thickness of 34.4%, whereas another group had about 15% (p=0.002). Also, PAPP-A levels had acceptable sensitivity and specificity for placental thickness detection (71.1% and 54.8%, respectively.
Conclusion: Our study showed that serum level of PAPP-A generally was low (≤0.8) in women with a thick placenta (>4 cm or >50% of placental length). The first trimester of pregnancy measurement of PAPP-A will be more predictable for healthy placenta.

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