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Showing 6 results for Naderi

Ensieh Shahrokh Tehrani Nejad1, Tayebeh Naderi, Shohreh Irani, Elham Azimi Nekoo,
Volume 5, Issue 4 (7-2007)

Background: Mullerian disorders are present in 5-25% of infertile women. Myoma, polyp and endometrial adhesions are among other involved factors in infertility.
Objective: The aim of this study was to determine the frequency distribution of pregnancy occurrence in infertile women after the diagnostic-surgical hysteroscopy on selected infertile cases including those with abnormal uterine.
Materials and Methods: One hundred and fifteen women with at least 12 months infertility who had abnormal uterine cavity and patients who had at least 4 unsuccessful ART cycles with no confirmed diagnosis of uterine cavity problem, underwent diagnostic hysteroscopy and if required hysteroscopic surgery. Follow up sonography and HSG performed 2-3 months later and all subjects were followed for pregnancy occurrence for 12 months.
Results: Mean age of subjects was 32.65 ± 6.2 years and mean of infertility duration was 8.33 ± 5.25 years. Based on the sonography and HSG performed prior to the hysteroscopy, respectively 69.6% and 41.8% of the subjects had abnormality. In 65.2% of the cases, hysteroscopy showed septum, myoma, endometrial adhesion and irregularity and all of them underwent hysteroscopic operation. Among the operated cases, in 27 cases pregnancy occurred during the first 6 postoperative months and in 2 cases during the second 6 postoperative months of whom one case was EP. Conclusion: There was no significant difference in the rate of pregnancy occurrence between those who had abnormal hysteroscopy and those who were normal (p= 0.63). This can show the variation of infertility causes and the fact that infertility is not just due to uterine problems. Therefore, the repetition of therapeutic measures and longer follow up of infertile cases are necessary.
Fatemeh Mostajeran, Maryam Naderi, Shahriar Adibi,
Volume 5, Issue 5 (7-2007)

Background: During the detorsion of a torsioned ovary, oxidant agents are released and melatonin as an antioxidant can reduce ischemia. We studied the histopathological changes after using melatonin on experimental torsioned ovary in cat.
Objective: The aim of this experimental study was to investigate the effects of Melatonin on histopathological changes in torsion – detorsion injury in cat ovary.
Materials and Methods: An adnexal torsion – detorsion model was created by using 20 adult cats randomly divided equally in to 2 groups of Saline and Melatonin. Ischemia was induced by iathrogenic 360° clockwise torsion of the cat adnex for 3 hr. Reperfusion was achieved for 3 hr. Melatonin or saline were injected intra peritoneally (10mg/kg) 30 min before ovarian detorsion in both groups. After 3 hr of ovarian detorsion, ovarian tissue was removed and fixed in 10% formalin solution, embedded in paraffin and evaluated for ischemic indices.
Results: Histological examination showed a significant improvement in ovarian morphology in the melatonin treated cats. Edema and vasoconstriction in saline group were more severe than Melatonin group (p-value = 0.009). Hemorrhage and leukocyte infiltration were also more obvious in saline group (p-value 0.0018)
Conclusion: Our results demonstrated that Melatonin administration reduced ovarian histopathological damage due to oxidative injury associated with torsion.
Homayoun Naderian, Hossein Nikzad, Akbar Aliasgharzadeh, Mohammad Ali Atlasi,
Volume 7, Issue 1 (7-2009)

Background: Polycystic ovarian syndrome (PCOS) is one of the most common endocrine disorders which cause anovulatory infertility and hyperandrogenism in young women. The common feature in PCOS women is increased ovarian androgen secretion which can effect on the prevalence of miscarriage rate.
Objective: The aim of this study was to investigate the effect of PCOS patient's serum on in vitro developmental stages of mouse embryo from two cells to hatching blastocyst.
Materials and Methods: After superovulating and fertilizing Balb/c mice, 219 two cells embryos were retrieved, 109 embryos were cultured in 10% PCOS patient's serum and 90% medium and 110 embryos were cultured in 10% normal serum and 90% medium to hatching blastocyst stage. The PCOS patient's serum which added to medium had higher hormonal concentrations than normal serum. The early developmental stages of embryos were studied in 2, 4, 8 cells, morula, early, late and hatching blastocyst stages.
Results: The statistical analysis confirmed the decreasing rate in the number of embryos in all developmental stages from 2 cells to hatching blastocyst in PCOS group in comparison with the normal group (p<0.05).
Conclusion: The PCOS patient's serum causes the decreasing rate of in vitro development of the early stage in mouse embryos.
Seyed Alireza Sobhani, Zahra Etaati, Sepideh Mirani, Paknoosh Saberi, Mahnaz Shiroodi , Hojjat Salmasian, Nadereh Naderi,
Volume 9, Issue 3 (7-2011)

Iron deficiency anemia (IDA) is a common problem in many developing countries. It is still considered the most common nutrition deficiency worldwide. Apart from its direct hematologic importance, IDA affects cellular and humoral immunity and predisposes the host to infections (1).
Pregnant women are highly prone to IDA. Controversial results are reported in studies targeting this group of patients. Tang et al showed a direct association between hemoglobin concentration and the count of CD4+ T-cell lymphocytes, serum levels of IL-2 and IgG, and an inverse association with susceptibility to infection (2). Ironically, Leush et al reported an increase in IgM and IgG in the second and third trimesters of pregnancy in women with IDA (3).
With regard to controversial results and the scarcity of studies focusing on pregnant women, we aimed to enlighten the relation between iron status and some immunological factors include some component of complement system, IgA, IgM, IgG subclasses of immunoglobulins and pro-inflammatory cytokines during the third trimester of pregnancy.
In a descriptive-analytic study participants  were recruited using convenient sampling from  the   women   in  the  third  trimester  of  pregnancy referred to the labor room of gynecology and obstetrics ward of Dr. Shariati Hospital of Bandar Abbas, Iran. Patients with signs and symptoms of thalassemia, infectious diseases or autoimmune diseases were excluded.
IDA were defined with two criteria, hemoglobin concentration of less than 10 mg/dL (its normal range during the third trimesters of pregnancy is 11-14mg/dL) (4) and ferritin less than 40 ng/dL. Patients were categorized into two groups: those with iron deficiency anemia (IDA) and those without this condition (no IDA).
Red cell indices including hemoglobin (Hb) levels, hematocrit (HCT), mean corpuscular volume (MCV), red blood cell distribution width (RDW), and mean corpuscular hemoglobin (MCH), serum iron (SI) and total iron binding capacity (TIBC), concentration of ferritin, C3 and C4 complements and IgA, IgM and IgG subclasses of immunoglobulins were determined. Data was analyzed using SPSS version 11.5 using Student t-test, Pearson’s correlation test and Kolmogorov-Smirnov’s test of normal distribution.
Ninety-two patients were studied. They were aged between 15 and 42 years (mean=25.69±6.2). According to our definition of IDA in pregnancy, 21 patients (22.8%) had IDA.
Our analysis of differences between the two groups in regard to immunologic markers showed that C4 levels are lower in the IDA group (p=0.009) and the levels of C3, IgM, IgG, IgA, IL-1, IL-6 and TNF-α were not statistically different in the two groups .
We noticed that higher levels of serum iron are correlated with higher levels of C3, C4 and IgG1. Due to important properties of IgG1 like complement fixation and opsonic activity, this subclass is dominant antibody to pneumococcal capsular polysaccharides and its deficiency is associated with current infections (5). Taken together noticing key roles of C3, C4 in complement-mediated bacteriolysis, opsonization, facilitated ingestion immune adherence (6) and association of C3, C4 with Iron serum levels found in this study we suggest that decreased level of Iron increases susceptibility of pregnant women to infections like chronic bacterial respiratory infections and recurrent genital herpes (5). Analyzing immunologic parameters differences between the two groups of IDA and no IDA we found that C4 levels are lower in the IDA group but not the levels of C3, IgM, IgG, IgA, IL-1, IL-6 and TNF-α .Our findings about IgM, IgG, IgA are in contradiction to scanty studies in this field. Tang et al (2) about significantly lower level of IgG, CD3+ and CD4+ cells, the ratio of CD4+/CD8+cells, serum IL-2 in second trimester of IDA pregnant woman and Leush et al (3) study showed increase of IgM and IgG in second and third trimesters of IDA groups.
Our findings about non-significant difference in C3 and significant difference in C4 levels in IDA and no IDA groups is  in agreement with Galan et al report about significantly positive correlation of C4 IgA, IgM and Serum ferritin (7). Despite of mounting evidence that TNF, IL-1, and IL-6 cytokines affect hemopoiesis and iron metabolism there was no significant association between IL-1, IL-6 and TNF-α and serum Iron, ferritin, TIBC in our study and inflammatory cytokines were statistically indifferent in the two IDA and no IDA groups. To our knowledge, there are no reports on inflammatory cytokine levels and Iron parameters in pregnant women, but a limited number of reports exploring this field in children and adults.
Bergman et al  which analyzed the in vitro production of IL-1beta, IL-2, IL-6, IL-10, and TNF-α by peripheral blood mononuclear cells from 20 patients with IDA report that  the secretion of the cytokines other than IL-2 did not differ from that of controls (8). In another study there was no difference in serum levels of IL-6 in iron deficiency anemia before and after iron supplementation in children with IDA but in the iron-deficiency group the production of IL-2 was found to be significantly lower than that in controls and became normal after iron supplementation (9). Safuanova et al work about adequate therapy by iron-containing drugs in IDA patients  resulted  in decreased concentrations of IL-1, IL-6, TNF-alpha and INF-gamma and recovering the functional status of the immune system (10). It is possible that discrepancy seen between our results and mentioned reports in non-pregnant patients is a reflection of dramatic change of immune function in pregnancy.
Analyze of the results of our study and similar researches leads us to the conclusion that  unlike extensive immunological changes have been observed in children, IDA has little effect on humoral immunity system of pregnant women, but decrease in  serum iron could predispose them to pyogenic infection  and may predict  increased susceptibility IDA pregnant women to infections.
Behnaz Khani, Nahid Bahrami, Ferdous Mehrabian, Hormoz Naderi Naeni,
Volume 9, Issue 3 (7-2011)

Background: Adhesion is a common complication of gynecology surgery so different barrier agents and solutions have been used during these operations to separate and protect tissues from adhesion after surgery. Adept is one of these solutions that have been postulated to reduce the chance of adhesion following gynecolgy surgery.
Objective: To evaluate the effect of 4% icodextrin in reducing adhesion formation in comparing with sterile water and human amniotic fluid in rabbits. Materials and Methods: In this prospective experimental study 30 white Newzealand female rabbits were selected and randomized in to three treatment groups. The rabbits were anesthetized and an abdominal incison was made, uterine horns were abrated with gauze until bleeding occurred. Before closing the abdomen, the traumatized area was irrigated either by 30cc of sterile water, 30cc of 4% Adept or 30cc of human amniotic fluid. The solutions were labeled only as solutions A (steriel water), B (icodextrin), or C (human amniotic fluid). On the seventh day after surgery, second laparotomy was performed to determine and compare adhesion formation in rabbits.
Results: There was significant difference between mean score of adhesions in 4% icodextrin group (2.1±0.70) in comparison to sterile water group (10.4±0.60) and amniotic fluid group (8.7±0.84). But the difference between mean score of adhesions in amniotic fluid group in comparison to sterile water group was not significant (8.7±0.84) versus (10.4±0.60).
Conclusion: The use of 4% icodextrin solution was more effective than human amniotic fluid and sterile water in reducing adhesion formation in a gynecological surgery model in rabbits
Sara Darbandi, Mahsa Darbandi, Hamid Reza Khorram Khorshid, Abolfaz Shirazi, Mohammad Reza Sadeghi, Ashok Agarwal, Safaa Al-Hasani, Mohammad Mehdi Naderi, Ahmet Ayaz, Mohammad Mehdi Akhondi,
Volume 15, Issue 10 (12-2017)

Nuclear transfer procedures have been recently applied for clinical and research targets as a novel assisted reproductive technique and were used for increasing the oocyte activity during its growth and maturation. In this review, we summarized the nuclear transfer technique for germinal vesicle stage oocytes to reconstruct the maturation of them. Our study covered publications between 1966 and August 2017. In result utilized germinal vesicle transfer techniques, fusion, and fertilization survival rate on five different mammalian species are discussed, regarding their potential clinical application. It seems that with a study on this method, there is real hope for effective treatments of old oocytes or oocytes containing mitochondrial problems in the near future.

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