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Showing 11 results for Khadem

Afsaneh Khademi, Leili Safdarian, Ashraf Alleyassin, Marzieh Agha-Hosseini, Ehsan Akbari Hamed, Hojatollah Saeidi Saeidabadi, Omid Pooyan,
Volume 2, Issue 2 (7-2004)

Background: The etiologic cause in near one third of male factor infertility is unknown. The percentage of men with idiopathic infertility who have been successfully treated by the empirical therapeutic modalities is not high. Objective: The aim of this study was to assay the effect of L-carnitine on sperm parameters in patients who needs intracytoplasmic sperm injection (ICSI) as a method for infertility treatment. Materials and Methods: The study population consisted of 65 men (mean age± SD: 34.4 ± 6.07) presenting with primary infertility due to idiopathic oligoasthenoteratozoospermia. L-carnitine was prescribed 1gram orally every 8 hours for 3 months. Before and after the ending of the L-carnitine treatment, semen analysis was performed. Results: The proportion of patients who had motile and grade C sperms rose significantly after treatment. Percentile of abnormal shaped sperms decreased significantly after treatment. In approximately 22%, complete asthenozoospermia changed to relative asthenozoospermia. Conclusion: Appearing motile sperms will potentially improve the technique of ICSI. The magnitude of the elevation in normal morphology is not clinically obvious, but it seems that it can be important in obtaining normal-shaped sperms for intracytoplasmic injection. Designing a study on selected patients with complete asthenozoospermia who have not other abnormalities in semen parameters can reveal the real effect of carnitine therapy in this category. Article
Nezhat Moossavifar, Nayereh Khadem, Alieh Torabizadeh,
Volume 4, Issue 1 (7-2006)

Background: It has been demonstrated that performing a mock embryo transfer (ET) significantly improves the pregnancy rate in IVF cycles. The mock ET could be performed prior to the stimulation cycle or immediately before real ET. The problem of the first procedure is the possibility of variation in the uterine position and or cervico–uterine angle.
Objective: The purpose of this study was to determine the consistency of the type of ET in mock ET prior to the treatment cycle with real ET.
Materials and Methods: A prospective comparison between the technique of mock embryo transfer and real embryo transfer. One hundred and sixty treatment cycles on 141 patients between January 2003 and September 2004 ended to ET and they were analyzed prospectively. In each cycle, patients underwent a mock ET in mid luteal phase prior to treatment cycle (the date when patients referred to have consultation about down regulation regimen).
Results: Of 160 mock ET the Wallace catheter passed easily in 144 (90%) of them. In the remaining 16 cycles (10%) a tenaculum and or a rigid cannula had to be used. From 144 cases of easy mock ET, real ET was easy in 121 (84%) cases while 23 (16%) cases had difficultly during real ET. In the 16 cases of difficult mock ET, there was 8 cases (50%) of difficult real ET and 8 cases (50%) of easy real ET (p=0.001, χ2=10.67). The overall clinical pregnancy rate for both difficult and easy transfer was 35%. The pregnancy rate for easy real ET was  37.2% and for difficult real ET was 25.87%. Despite of the difference, the statistical analysis shows no significance difference (χ2=1.21). The difference between mean age for both difficult and easy real transfer was not significant.
Conclusion: Mock ET before beginning of the treatment cycle is highly consistent with real ET.
Afsaneh Khademi, Ashraf Alleyassin, Marzieh Agha-Hosseini, Nasrin Dadras, Allaleh Asghari Roodsari, Leila Tabatabaeefar, Mehrnoosh Amini,
Volume 4, Issue 1 (7-2006)

Background: Female sexual dysfunction (FSD) is a real problem that affects 25-63% of women. There is no valid Persian version of sexual function questionnaire (FSQ).
Objectives: The aim of this study was to test the reliability and validity of Persian version of sexual function questionnaire.
Materials and Methods: In this cross-sectional study, 547 women were questioned by Persian version of SFQ. Factor analysis produced five domains of female sexual function. Internal consistency, test-retest reliability, and discriminant validity were calculated.
Results: Five-factor structure accounted for 63% of the variance. Arousal-orgasm domain was as same as arousal-sensation, arousal-lubrication, and orgasm domains of the original version. Enjoyment-desire domain was similar to enjoyment and desire domains except one question. Pain and partner domains were consistent with original domains. Internal consistency, test-retest reliability, and discriminant validity were reasonable in Persian version of SFQ.
Conclusion: Persian version of SFQ is almost valuable and reliable to use for Iranian population with exception of one question. Results of the omitted question from enjoyment domain should interpret separately as unusual sex domain.
Nayereh Khadem, Hossein Ayatollahi, Fatemeh Vahid Roodsari, Sedigheh Ayati, Ehsan Dalili, Masoud Shahabian, Taraneh Mohajeri, Mohamad Taghi Shakeri,
Volume 10, Issue 1 (7-2012)

Background: The physiological changes in thyroid gland during pregnancy have been suggested as one of the pathophysiologic causes of preeclampsia.
Objective: The aim of this study was comparison of serum levels of Tri?iodothyronine (T3), Thyroxine (T4), and Thyroid?Stimulating Hormone (TSH) in preeclampsia and normal pregnancy.
Materials and Methods: In this case?control study, 40 normal pregnant women and 40 cases of preeclampsia in third trimester of pregnancy were evaluated. They were compared for serum levels of Free T3 (FT3), Free T4 (FT4) and TSH. The data was analyzed by SPSS software with the use of t?student, Chi?square, Independent sample T-test and Bivariate correlation test. p?0.05 was considered statistically significant.
Results: The mean age was not statistically different between two groups (p=0.297). No significant difference was observed in terms of parity between two groups (p=0.206). Normal pregnant women were not significantly different from preeclampsia cases in the view of FT3 level (1.38 pg/ml vs. 1.41 pg/ml, p=0.803), FT4 level (0.95 pg/ml vs. 0.96 pg/ml, p=0.834) and TSH level (3.51 ?IU/ml vs. 3.10 ?IU/ml, p=0.386).
Conclusion: The findings of the present study do not support the hypothesis that changes in FT3, FT4 and TSH levels could be possible etiology of preeclampsia.
Nayyereh Khadem, Mohammad Ebrahim Rahmani, Alireza Sanaei, Mliheh Afiat,
Volume 10, Issue 6 (4-2012)

Background: Since preterm delivery is an important problem in obstetrics, it is necessary to know the risk factors. Periodontal disease is an infectious disease and infection is risk factor for preterm delivery. Respecting to the mechanisms of preterm delivery and because involved mediators in this procedure are synthesized in periodontal disease, gum disease is investigated as risk factor for preterm delivery.
Objective: The aim of this study was to determine the association between preterm, low birth weight with periodontal diseases to improve the mothers’ and the children’s health.
Materials and Methods: This cases-control study was done on 70 women (mean age 25.01 yrs.) 35 women with preterm delivery, gestational age <37 weeks and birth weight <2500 gr as case group and 35 women with term delivery, gestational age >37 weeks and birth weight >2500 gr as control group referring to Imam Reza Hospital. Mean Probing Depth (MPD), percent of sites with more than 3 mm in probing, bleeding Index (BI), Plaque Index (PI), and Extent and Severity Index (Ext. and Sev.) were measured using a mirror and a standard Williamchr('39')s periodontal probe.
Results: Significant difference was found in Mean Probing Deep (MPD), percentage of sites with more than 3 mm in probing, BI, PI, Ext. and Sev. indices in case and control groups. There was no significant difference in patient’s job, age, education, and husband’s job and education. No difference was observed between two groups in monthly income and gravidity.
Conclusion: Gum disease can be a risk factor for preterm delivery.
Hamid Reza Ashrafzadeh, Tahere Nazari, Masoud Dehghan Tezerjani, Maryam Khademi Bami, Saeed Ghasemi-Esmailabad, Nasrin Ghasemi,
Volume 15, Issue 8 (9-2017)

Background: Tumor necrosis factor-alpha (TNF-α) is a multifunctional cytokine that regulates different cellular activities related to spermatogenesis. Tumor necrosis factor-alpha receptor 1 (TNFR1) mediates TNF-α activity and polymorphism in TNFR1 could lead to gene dysfunction and male infertility.
Objective: The aim of this study is to determine the association of TNFR1 36 A/G polymorphism with the idiopathic azoospermia in Iranian population.
Materials and Methods: This case-control study included 108 azoospermic and 119 fertile men. This research investigated the frequency of TNFR1 36 A/G polymorphism in cases who were idiopathic azoospermic men referred to Yazd Research and Clinical Center for Infertility, Iran in comparison with controls. polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP) method was used to investigate the polymorphism in both case and control groups. PCR fragments were digested by Mspa1I enzyme and products were appeared by gel electrophoresis. The abundance of A→G was calculated in the azoospermic and healthy men.
Results: According to the present study, GG and AG genotypes frequency in the azoospermic men group were higher than the control group (OR= 2.298 (1.248-4.229), p=0.007), (OR=1.47 (0.869-2.498, p=0.149). Our findings also showed that G allele frequency in azoospermic men had significant difference compared to the control group (OR=2.302 (1.580-3.355), p<0.001).
Conclusion: It seems that the GG genotype and G allele have an association with increased risk of non-obstructive azoospermia
Seyedeh-Fatemeh Hekmatzadeh, Fatemeh Bazarganipour, Nazafarin Hosseini, Helen Allan, Somayeh Jalali, Zahra Abbasian, Akram Barani, Fereshteh Balochi, Saeideh Khademi, Tahereh Mahmoudi, Roghayeh Niknam, Zahra Khashavi, Seyed Abdolvahab Taghavi,
Volume 16, Issue 3 (March 2018)

Background: Clinical measurement of quality of life (QoL) for assessing reproductive problems should be considered as a standard investigation at the initial and continuing medical consultations with infertile people.
Objective: The purpose of this study was comprehensive testing the psychometric properties of the Iranian version of fertility quality of life (FertiQoL).
Materials and Methods: This cross-sectional study was conducted on300 women referred to infertility clinic. After linguistic validation, a semi-structured interview was conducted to assess face validity. Consequently exploratory factor analysis was performed to indicate the scale constructs. Discriminate validity was assessed using the known groups comparison. Convergent validity was evaluated by assessing the correlation between similar content on the 12-Item Short Form Health Survey (SF12), Hospital Anxiety and Depression Scale and FertiQol. In addition, reliability analysis was carried out with internal consistency.
Results: The reliability of the Iranian version of the FertiQoL was satisfactory in all dimensions (0.77-0.83). Six factors (emotional, mind/body, relational, social, environmental, and tolerability) were extracted from the results of exploratory factor analysis. Discrimination validity showed that FertiQoL can differentiate between female patients with differing duration of infertility and number of children. Moreover, the results of convergent validity showed a favorable correlation between the related dimensions of SF12 (0.43-0.68), Hospital Anxiety and Depression Scale (0.47-0.52) and FertiQoL.
Conclusion: The Iranian version of FertiQoL is valid and reliable for assessing infertility problems and the effects of treatment on QoL of infertile patients referred for diagnosis and treatment at infertility clinic.

Zeinab Ebrahim Abadi , Maryam Khademi Bami, Maryam Golzadeh, Seyed Mehdi Kalantar, Mohammad Hasan Sheikhha,
Volume 16, Issue 8 (August 2018)

Background: Tumor protein p53 (TP53) is a tumor suppressor transcriptional regulator protein which plays a critical role in the spermatogenesis. One of the most important regulators of p53 is Murine double minute 2 (MDM2), which acts as a negative regulator of the p53 pathway. Based on the key role of p53 and MDM2 in germ cell apoptosis, polymorphisms that cause a change in their function might affect germ cell apoptosis and the risk of male infertility. Objective: This study was designed to examine associations of TP53 72 Arg>Pro (rs1042522), and MDM2 309 T>G (rs937283) polymorphisms with spermatogenetic failure in an Iranian population.
Materials and Methods: A case-control study was conducted with 150 nonobstructive azoospermia or severe oligozoospermia and 150 fertile controls. The two polymorphisms, 72 Arg>Pro in TP53 and 309 T>G in MDM2, were genotyped using PCR-RFLP and ARMS-PCR respectively.
Results: Our analyses revealed that the allele and genotype frequencies of the TP53 R72P polymorphism were not significantly different between the cases and controls (p=0.41, p=0.40 respectively). Also, no significant differences were found in the allelic (p=0.46) and genotypic (p=0.78) distribution of MDM2 309 T>G polymorphism between patients and controls.
Conclusion: The results of this study indicate that polymorphisms of TP53 and MDM2 genes are unlikely to contribute to the pathogenesis of male infertility with spermatogenetic failure.
Nayereh Ghomian, Farveh Vakilian, Bahram Shahri, Vesam Rostaminejad, Majid Khadem-Rezaiyan,
Volume 17, Issue 4 (April 2019 2019)

Background: Preeclampsia is one of the most common pregnancy complications, which is one of the major causes of fetal and maternal mortality.
Objective: To compare the serum Brain Natriuretic Peptide (BNP) level in patients with severe preeclampsia and normal pregnancy and investigate associated cardiovascular complications.
Materials and Methods: This case-control study was performed on 94 women with a singleton pregnancy (severe preeclampsia and normal pregnancy) at Imam Reza Hospital in Mashhad, Iran. The venous blood samples were collected to evaluate the serum BNP level. All patients were subjected to echocardiography performed by a single cardiologist.
Results: The mean pro-BNP levels were 480.36 ± 754.52 and 67.46 ± 106.24 pg/dL in the severe preeclampsia and normal pregnancy patients, respectively (p < 0.001). However, adjusted BNP for maternal and gestational age was not different in the two groups (ANCOVA, p = 0.69). Furthermore, the two study groups showed no significant difference in terms of the cardiac parameters, including ejection fraction (EF), left ventricle end-diastolic and -systolic diameters (LVEDD and LVESD, respectively), tricuspid annular plane systolic excursion (TAPSE), and ratio of the early transmitral flow velocity to the early diastolic tissue velocity (E/Em). However, the serum BNP level showed a significant correlation with EF (r = -0.39, p = 0.008), TAPSE (r = -0.47, p = 0.001), and E/Em ratio (r = 0.48, p = 0.001) in patients with severe preeclampsia.
Conclusion: It seems that BNP can be used as a predictor for some of the main cardiac functional indices (i.e., E/Em, EF, and TAPSE) in severe preeclampsia patients.
Nayere Khadem Ghaebi, Malihe Mahmoudiniya, Mona Najaf Najafi, Elnaz Zohdi, Matin Attaran,
Volume 18, Issue 2 (February 2020)

Background: The use of frozen embryo transfer (FET) is increasing worldwide in the treatment of infertility by in vitro fertilization. Different methods of endometrial preparation for FET have been suggested.
Objective: The aim of this study was to compare the pregnancy outcomes after treatment with letrozole and those after treatment with the combination of gonadotropin-releasing hormone (GnRH) agonist and estradiol in FET.
Materials and Methods: This randomized controlled trial study was conducted on 142 infertile women with a history of previous FET failure. Participants were randomly assigned to two groups (n = 71 each). The GnRH group received 500 µg of buserelin plus 4mg estradiol (which increased to 8 mg if endometrial thickness was less than 5 mm), and the letrozole group received 5 mg of letrozole plus 75 IU of recombinant human follicle-stimulating hormone). At least two high-quality embryos were transferred to each subject in both groups. The outcome measures were clinical pregnancy rate and fetal heart rate detection.
Results: Subjects in the study groups had similar demographic characteristics and baseline clinical condition. Mean endometrial thickness in the letrozole and GnRH agonist groups were 8.90 ± 0.88 mm and 8.99 ± 0.85 mm, respectively (p = 0.57). The number of positive results of the beta human chorionic gonadotropin test and detection of fetal heartbeat were not significantly different between the groups (p > 0.05).
Conclusion: The administration of letrozole and GnRH may produce similar pregnancy outcomes in FET.
Fatemeh Zal, Pardis Ahmadi, Maryam Davari, Fatemeh Khademi, Mojgan Akbarzadeh Jahromi, Zahra Anvar, Bahia Namavar Jahromi,
Volume 18, Issue 6 (June 2020)

Background: Oxidative stress and GSH-dependent antioxidant system plays a key role in the pathogenesis of polycystic ovary syndrome (PCOS).
Objective: We compared glutathione peroxidase (GPx) and glutathione reductase activities and reduced glutathione (GSH) levels in serum and follicular fluid (FF) of the first-retrieved follicle and their impact on quality of oocyte and embryo in PCOS women undergoing IVF.
Materials and Methods: This cross sectional study was conducted on 80 pairs of blood samples and FF of the first-retrieved follicle from PCOS women, at the Infertility center of Ghadir Mother and Child Hospital. The mean activity of GPx and GR, also GSH levels in the serum and FF were compared to the quality of the first follicle and resultant embryo.   
Results: Retrieved oocytes included 53 (66.25%) MII, 17 (21.25%) MI, and 10 (12.5%) germinal vesicles; after IVF 42 (52.50%) embryos with grade I and 11 (13.75%) with grade II were produced. The mean values for all three antioxidants were higher in the FF compared to serum (p < 0.001). Also all of the mean measured levels were significantly higher in the FF of the MII oocytes compared to that of oocytes with lower grades (p = 0.012, 0.006 and 0.012, respectively). The mean GPX activity and GSH levels were significantly higher in the serum (p = 0.016 and 0.012, respectively) and FF (p = 0.001 for both) of the high-quality grade I embryos.
Conclusion: GSH-dependent antioxidant system functions more efficiently in the FF of oocytes and embryos with higher quality.

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