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Maryam Eidi, Akram Eidi, Omid Pouyan, Pouneh Shahmohammadi, Reza Fazaeli, Massih Bahar,
Volume 8, Issue 3 (7-2010)
Abstract

Background: The trace element copper has been identified as a highly toxic element for sperm. It is known to affect sperm motility in humans and experimental implantation of copper in the epididymis vas deferens and scrotum of mammals has been demonstrated to affect fertility detrimentally. Objective: Sperm concentration motility vitality and morphology are parameters used to evaluate potential male fertility. Since copper is believed to be important for spermatogenesis; we conducted a study to investigate the correlation between seminal plasma copper concentration and human semen parameters in 232 males.
Materials and Methods: We selected 232 subfertile or infertile men who referred to Omid Fertility Clinic randomly. Samples were categorized into normospermic (n=32) oligozospermic (n=73) asthenozospermic (n=111) and azospermic (n=16) groups according to their spermiogrames. Total seminal plasma copper concentration was determined by furnace atomic absorption spectrophotometer.
Results: The results showed that seminal plasma copper concentrations in oligozospermic asthenozospermic and azospermic groups are significantly higher than normozospermic group (p<0.01). Also, negative correlations were found between seminal plasma copper concentration and sperm count (p<0.05), sperm motility (p<0.01), sperm vitality (p<0.01), normal morphology (p<0.01) and pH (p<0.01) in all groups.
Conclusion: It was suggested that excess copper in seminal plasma was detrimental for male reproductive capacity by reducing sperm count, motility, vitality and morphology.
Hoda Fazaeli, Faezeh Davoodi, Naser Kalhor, Reza Tabatabaii Qomi ,
Volume 16, Issue 3 (March 2018)
Abstract

Background: One of the most important involved factors in pregnancy occurrence following intrauterine insemination (IUI) is semen sample preparation. Recently, supernatant product of adipose tissue derived mesenchymal stem cells (SPAS) method has been shown to improve semen parameters.
Objective: To compare the effect of preparation methods in order to IUI, SPAS and density gradient centrifugation (DGC).
Materials and Methods: This trial was done on 80 couples with male factor infertility who attend jihad daneshgahi infertility treatment center of Qom province, undergoing ovarian stimulation and IUI cycle. Various semen parameters including motility, count, DNA fragmentation and capacitation were evaluated before and after preparation. The effect of semen preparation methods and influence of various semen parameters on pregnancy occurrence were examined.
Results: The overall clinical pregnancy rate was 17.5% per patient with no miscarriage. The pregnancy rate for DGC and SPAS were 5% (2 of 40) and 30% (12 of 40) respectively. Since there is no significant difference in improving motion parameters between two groups (except recovery of total number of motile spermatozoa), it seems that these parameters alone are not sufficient to predict IUI pregnancy outcome whereas in samples with >25 million motile spermatozoa in inseminate, there was a clear trend for a higher pregnancy rate for the sample processed using SPAS.
Conclusion: Considering SPAS as a new and effective method leading to provide a combination of various improved semen parameters, is expected in near future.


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