Search published articles

Showing 4 results for Davoodi

Davoodi Sohrabi, Mohsen Alipour, Ali Awsat Mellati,
Volume 5, Issue 3 (7-2007)

Metronidazole and its derivatives have both antiprotozoal and anti bacterial effects. The reproductive toxicity of metronidazole has been observed in some studies. The aim of this study was to determine the detrimental effects of metronidazole on spermatogenesis and testicular androgenesis in male adult rats. Eighteen male Wistar rats (70-90 days old) were randomly divided into three groups. Animals in group I (Control group) were administered with the water only. Animals in groups II and III were administered with metronidazol at the doses of 200 or 400 mg/kg/day for 60 days. Quantitative analysis of spermatogenesis was carried out by counting the relative number of each variety of germ-cells at the stage VII of the seminiferous epithelium cycle, i.e. type-A spermatogonia (ASg), pre-leptotene spermatocytes (pLSc), and step 7 spermatids (7Sd). Plasma follicle-stimulating hormone (FSH), luteinizing hormone (LH) and testosterone were measured by radioimmunoassay (RIA). In groups II and III, there was a significant decrease in the testes, accessory sex organ weights, plasma concentrations of LH, FSH and testosterone with massive degeneration of all the germ cells at stage VII. Our data concluded that metronidazole has a suppressive influence on spermatogenesis and sex hormones in rats.
Fariba Binesh, Ali Akhavan, Mahnoosh Davoodi,
Volume 11, Issue 9 (12-2013)

Background: It is noted that oral contraceptive pills increase the risk of abnormal Pap smear but results have been inconsistent across the populations.
Objective: This study aimed to evaluate the association between oral contraceptive pill (OCP) consumption and abnormal Pap smear in women who referred to Shahid Sadoughi and Madar hospitals in Yazd.
Materials and Methods: A cross sectional descriptive study was carried out and a database of all Pap smear reports from 2009-2011 at Cytopathology Department of Shahid Sadoughi and Madar hospitals in Yazd, Iran was reviewed. A total number of 1286 women with history of OCP consumption were selected as the case group and 1218 women applying other contraceptive methods were selected as control group for evaluation. Both case and control groups were matched by age, parity and socioeconomic status. All of the women in this study maintained a single partner as their husband and none of them were considered as smokers. The duration of OCP use was at least 5 years.
Results: Abnormal Pap smear results were observed in 0.4% of cases and 0.2% of controls. There was no significant association between OCP consumption and abnormal Pap smear (p=0.727).
Conclusion: Our findings did not show any specific association between OCP consumption and abnormal Pap smear results. In addition, the number of abnormal Pap smears in women who consumed OCP was lower than that of western countries. More prospective studies are required.
Hoda Fazaeli, Faezeh Davoodi, Naser Kalhor, Reza Tabatabaii Qomi ,
Volume 16, Issue 3 (March 2018)

Background: One of the most important involved factors in pregnancy occurrence following intrauterine insemination (IUI) is semen sample preparation. Recently, supernatant product of adipose tissue derived mesenchymal stem cells (SPAS) method has been shown to improve semen parameters.
Objective: To compare the effect of preparation methods in order to IUI, SPAS and density gradient centrifugation (DGC).
Materials and Methods: This trial was done on 80 couples with male factor infertility who attend jihad daneshgahi infertility treatment center of Qom province, undergoing ovarian stimulation and IUI cycle. Various semen parameters including motility, count, DNA fragmentation and capacitation were evaluated before and after preparation. The effect of semen preparation methods and influence of various semen parameters on pregnancy occurrence were examined.
Results: The overall clinical pregnancy rate was 17.5% per patient with no miscarriage. The pregnancy rate for DGC and SPAS were 5% (2 of 40) and 30% (12 of 40) respectively. Since there is no significant difference in improving motion parameters between two groups (except recovery of total number of motile spermatozoa), it seems that these parameters alone are not sufficient to predict IUI pregnancy outcome whereas in samples with >25 million motile spermatozoa in inseminate, there was a clear trend for a higher pregnancy rate for the sample processed using SPAS.
Conclusion: Considering SPAS as a new and effective method leading to provide a combination of various improved semen parameters, is expected in near future.

Alamtaj Samsami, Leila Ghasempour, Sara Davoodi, Shaghayegh Moradi Alamdarloo, Jamshid Rahmati, Ali Karimian, Hamide Homayoon,
Volume 17, Issue 12 (December 2019)

Background: The endometrial preparation with stimulating natural cycles for frozen embryo transfer (FET) have benefits like lower cost and ease of use.
Objective: Comparing the clinical outcome of letrozole versus hormone replacement (HR) for endometrial preparation in women with normal menstrual cycles for FET in artificial reproduction techniques.
Materials and Methods: A total of 167 participants who had frozen embryos and regular ovulatory cycles were randomly divided into two groups for endometrial preparation. One group (82 women) was stimulated with letrozole 5mg/day and the other group (85 women) was hormonally stimulated by oral estradiol valerate (2 mg three times a day). All participants were followed serially by ultrasonography. Any patient who did not reach optimal endometrial thickness was excluded from the study. Implantation, biochemical and clinical pregnancy and abortion rate were reported.
Results: There was no significant difference in the mean age, duration, and primary or secondary infertility, cause of the infertility, number, and quality of transferred embryos between the groups. The mean estradiol level on the day of transfer was 643 ± 217 in the HR group and 547 ± 212 in the letrozole group (P = 0.01), which was significantly different. The clinical pregnancy rate was 38.7 in the letrozole group, higher than the HR group (25.3) but not significantly different (P=0.06).
Conclusion: For endometrial preparation in women with a normal cycle, letrozole yields higher pregnancy rate although it is not significant; due to its cost, ease in use, and lower side effects, letrozole is a good choice.

Page 1 from 1     

© 2020 All Rights Reserved | International Journal of Reproductive BioMedicine

Designed & Developed by : Yektaweb