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Showing 4 results for Beigi

Mojdeh Salehnia, Mitra Arianmanesh, Mandana Beigi,
Volume 4, Issue 1 (7-2006)

Background: The preparation of endometrium for embryo reception is dependent on the ovarian hormones, which are affected by ovarian hyperstimulation procedure.
Objective: The aim of this study was to evaluate the changes in morphometrical indices of endometrium by the daily injection of progesterone after mouse ovarian induction.
Materials and Methods: Adult virgin female mice were selected and divided into control and experimental groups. Experimental groups were superovulated using human menopasual gonadotropic hormone (HMG), and human chorionic gonadotropic hormone (HCG), then they, were subdivided into two groups, which one group was also injected daily by progesterone. All control and hyperstimulated groups were rendered pseudopregnant by cervical stimulation. Three and four days after the HCG injection, the samples of uterine horns were aparted and processed for light microscopic studies.
Results: Our results showed that in the progesterone-injected group, the height of surface and glandular epithelium was decreased on day three (17.6±3.55, 10.02±2.6) and day four (16.9±4.24, 1.6±0.84) respectively, and it had low columnar morphology in comparison with the hyperstimulated and control groups. Also the intercellular spaces of stroma in progesterone-injected group were narrower than these in the other groups.
Conclusion: Ovarian hyperstimulation followed by progesterone injection alter the morphometrical indices of surface and glandular epithelium of endometrium, which could affect on its receptivity.
Iraj Amiri, Narges Mirahadi, Ali Amini, Maryam Parvini, Khadijeh HeidarBeigi,
Volume 7, Issue 4 (7-2009)

Background: Mammalian oocytes are exposed to a mixture of many different growth factors and cytokines which provides an optimized microenvironment for oocyte maturation. In the lack of this natural microenvironment in vitro the quality of oocyte and embryos appears to be suboptimal. Objective: This study was undertaken to investigate the effects of EGF and LIF on in vitro maturation fertilization and cleavage rates in mouse oocytes. Materials and Methods: The GV oocytes were collected from female NMRI mice and randomly divided into control and 3 treatment groups. Oocytes in treatment groups were cultured in the maturation medium supplemented with 50 ng/ml rhLIF (Treatment 1) 10ng/ml EGF (Treatment 2) and 50 ng/ml LIF+ 10ng/ml EGF (Treatment 3) for 24 hours at 37°C in humidified 5% CO2 in air. The matured oocytes were fertilized in vitro and cultured for 96 hours. Finally the developmental rates were assessed and embryos were stained using Hoechst 33258.
Results: There was a higher maturation rate in treatment groups compared to the control group. There was not any significant difference in the rate of fertilization among the groups. The rates of cleavage (79.1%) and blastocyst formation (62.2%) were significantly higher in LIF + EGF group comparing to the other groups. The rates of hatching in groups treatment 1 (35.2%) and 3(41%) was significantly higher comparing to the other groups. Also the mean of total cell number in treatment groups significantly was higher than control (p< 0.05).
Conclusion: The findings of this study suggest a beneficial effect of LIF and EGF on mouse oocyte maturation and cleavage rates.
Sepideh Khodaverdi, Soheila Amini-Moghaddam, Fariba Almassi Nokiani , Neda Hashemi , Robabeh Mohammad Beigi ,
Volume 16, Issue 6 (Jun 2018)

Background: It has been shown that Carbohydrate antigen (CA) 125 and CA 19-9 tumor markers are useful for diagnosis and follow up of ovarian carcinoma.
Case: In this case, we reported the high level of CA-125 and CA 19-9 with large right ovarian intact endometrioma and extensive involvement of omentum. Conclusion: Human Epididymis protein (HE4) and Risk of ovarian malignancy algorithm (ROMA) can be useful in differentiation between malignancies and benign pathologies with a good sensitivity and specificity value
Afsane Ghasemi, Fatemehsadat Amjadi, Seyedeh Masoumeh Ghazi Mirsaeed, Robabeh Mohammad Beigi, Samaneh Ghasemi, Yousef Moradi, Seyedeh Tahereh Ghazi Mirsaeed,
Volume 17, Issue 10 (October 2019)

Background: In about 40% of the couples, the cause of infertility problems is attributed to men because of low sperm production and disturbed motility of sperm. Pieces of evidence show that Myo-inositol has a potential role for the treatment of sperm morphology and male fertility.
Objective: This study aimed to determine the effect of Myo-inositol on the sperm parameters and fertility rate in patients with oligoasthenospermia treated by intrauterine insemination (IUI).
Materials and Methods: This study was a randomized clinical trial conducted on 37 patients with oligoasthenospermia treated by IUI during 2016-2017. In this study, the patients were randomly divided into two groups of oligoasthenospermia treated with (Case group) and without Myo-inositol (Control group). The case group received 0.5 ml of Myo-inositol with a concentration of 2 mg/ml and incubated at 37ºC incubator for 2 hr, but the control group had no interventions.
Results: The results of this study showed that although there was no significant difference in sperm parameters including sperm motility and concentration before processing with Myo-inositol in the case group, but there was a significant increase in sperm motility during the treatment with Myo-inositol. The therapeutic effect of this method was confirmed on induction of pregnancy in 18% of the treated patients, in such a way that was about twice greater than those who did not receive the drug.
Conclusion: According to the results of this study, the use of Myo-inositol is efficient enough to change sperm parameters to increase the chance of fertility.

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