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Showing 16 results for Amini

Afsaneh Khademi, Ashraf Alleyassin, Marzieh Agha-Hosseini, Nasrin Dadras, Allaleh Asghari Roodsari, Leila Tabatabaeefar, Mehrnoosh Amini,
Volume 4, Issue 1 (7-2006)

Background: Female sexual dysfunction (FSD) is a real problem that affects 25-63% of women. There is no valid Persian version of sexual function questionnaire (FSQ).
Objectives: The aim of this study was to test the reliability and validity of Persian version of sexual function questionnaire.
Materials and Methods: In this cross-sectional study, 547 women were questioned by Persian version of SFQ. Factor analysis produced five domains of female sexual function. Internal consistency, test-retest reliability, and discriminant validity were calculated.
Results: Five-factor structure accounted for 63% of the variance. Arousal-orgasm domain was as same as arousal-sensation, arousal-lubrication, and orgasm domains of the original version. Enjoyment-desire domain was similar to enjoyment and desire domains except one question. Pain and partner domains were consistent with original domains. Internal consistency, test-retest reliability, and discriminant validity were reasonable in Persian version of SFQ.
Conclusion: Persian version of SFQ is almost valuable and reliable to use for Iranian population with exception of one question. Results of the omitted question from enjoyment domain should interpret separately as unusual sex domain.
Iraj Amiri, Narges Mirahadi, Ali Amini, Maryam Parvini, Khadijeh Heidarbeigi,
Volume 7, Issue 4 (7-2009)

Background: Mammalian oocytes are exposed to a mixture of many different growth factors and cytokines which provides an optimized microenvironment for oocyte maturation. In the lack of this natural microenvironment in vitro the quality of oocyte and embryos appears to be suboptimal. Objective: This study was undertaken to investigate the effects of EGF and LIF on in vitro maturation fertilization and cleavage rates in mouse oocytes. Materials and Methods: The GV oocytes were collected from female NMRI mice and randomly divided into control and 3 treatment groups. Oocytes in treatment groups were cultured in the maturation medium supplemented with 50 ng/ml rhLIF (Treatment 1) 10ng/ml EGF (Treatment 2) and 50 ng/ml LIF+ 10ng/ml EGF (Treatment 3) for 24 hours at 37°C in humidified 5% CO2 in air. The matured oocytes were fertilized in vitro and cultured for 96 hours. Finally the developmental rates were assessed and embryos were stained using Hoechst 33258.
Results: There was a higher maturation rate in treatment groups compared to the control group. There was not any significant difference in the rate of fertilization among the groups. The rates of cleavage (79.1%) and blastocyst formation (62.2%) were significantly higher in LIF + EGF group comparing to the other groups. The rates of hatching in groups treatment 1 (35.2%) and 3(41%) was significantly higher comparing to the other groups. Also the mean of total cell number in treatment groups significantly was higher than control (p< 0.05).
Conclusion: The findings of this study suggest a beneficial effect of LIF and EGF on mouse oocyte maturation and cleavage rates.
Mohammad Hossein Baghiani Moghadam, Amir Hosein Aminian, Ali Mohammad Abdoli, Najmeh Seighal, Hosein Falahzadeh, Nasrin Ghasemi,
Volume 9, Issue 4 (7-2011)

Background: The prevalence of infertility is variable between 5-30% around the world. In Iran, more than 2 million couples suffer from infertility. Infertility causes depression, anxiety, social isolation and sexual dysfunction.
Objective: This descriptive study was undertaken to determine general health in infertile couples.
Materials and Methods: One hundred and fifty infertile couples attending Yazd Research and Clinical Center for Infertility were randomly selected during March till September 2009. The GHQ-28 questionnaires were completed by researchers, based on face to face interview. It contains 28 items, which have been divided to four sub- items. The results come out by scoring the patients answer from 0 to 84. All data were analyzed by Chi-square and t-test in SPSS software.
Results: GHQ scores of all sub-scales and total in women were more than men, which shows general health condition in women is worse than men. There was no relation between the duration of infertility and general health scores.
Conclusion: This study suggests that the infertility has significant effect (p=0.001) on health situation of infertile couples, especially infertile women. They are at risk of somatic symptoms (p=0.0001), social dysfunction (p=0.0001) and severe depression (p=0.0001). GHQ could provided help and support in order to improve the health situation of infertile couples.
Mohammad Hosein Baghianimoghadam, Amir Hossein Aminian, Behnam Baghianimoghadam, Nasrin Ghasemi, Ali Mohammad Abdoli, Najmeh Seighal Ardakani, Hosein Fallahzadeh,
Volume 11, Issue 6 (9-2013)

Background: Infertility is accompanied by numerous psychological and social problems. Infertile couples are more anxious and emotionally distressed than other fertile people. Previous studies suggested that infertility is more stressful for women than men.
Objective: The purpose of this study was to determine the status of general health of infertile couples.
Materials and Methods: This cross-sectional study evaluated general health of 150 infertile couples attending to Yazd Research and Clinical Center for Infertility that were selected consequently. The data were gathered by the researchers, based on face to face interview before and after three months of treatment by two questionnaires. The first questionnaire had questions on demographic information and the second one was the General Health Questionnaire-28 (GHQ-28). This questionnaire has four sub- scales areas. All data were transferred directly to SPSS 15 and analyzed.
Results: The mean age of women was 28.3 and men were 32.4 years. The scores for all sub- scales of GHQ in women were more than men. There was significant difference between age and general health at physical symptoms scales (p=0.002), anxiety and sleep disorders (p=0.003). The age group 25-29 years had higher scores (more than 7) than other age groups. There was significant difference between the scale of social dysfunction and results of treatment.
Conclusion: Our results, similar to the previous studies have revealed negetive social and mental effects of infertility on women is more than men, so there is need that they be educated specially.
Khosro Sadeghniat Haghighi, Omid Aminian, Farzaneh Chavoshi, Leila Sadat Bahaedini, Shahin Soltani, Fatemeh Rahmati Najarkolaei,
Volume 11, Issue 8 (11-2013)

Background: The reproductive system is one of the organs that are affected by lead. Lead can cause loss of libido and fertility in men, and menstrual disturbances and spontaneous abortion in woman.
Objective: The purpose of this cross-sectional study was assessment of dose-response relationship between blood lead level (BLL) and sex hormones levels in lead exposed male workers.
Materials and Methods: One hundred and thirteen male workers enrolled. All workers had at least 6 months of lead exposure and no history of diseases or conditions affecting reproductive system. Blood lead level and hormones levels measured with atomic absorption spectrophotometer and radioimmunoassay method, respectively.
Results: Average duration of exposure was 15.92±6.95 years. Mean BLL was 41.41μg/dl±16.99. All of the sex hormones values were in normal range. Pearson correlation showed that sex hormones levels had no significant correlation with blood lead level. Also, there was no significant difference in sex hormones levels between workers with BLL <40μg/dl and workers whose BLL was >40 μg/dl.
Conclusion: This study showed that BLL cannot serve as a predictor of male sex hormonal changes. However, it is not possible to rule out the effect of lead on the reproductive system after long-term exposure.
Mohammad Ebrahim Parsanezhad, Nasrin Dadras, Najmeh Maharlouei, Leila Neghahban, Peghah Keramati, Madihe Amini,
Volume 11, Issue 11 (12-2013)

Background: Unexplained infertility is still a challenging issue as to its causes, appropriate management and treatment. Evidence implicates early embryopathy or implantation failure as likely causes.
Objective: This study aims to investigate the effect of local endometrial injury on pregnancy rate in selected unexplained infertile patients.
Materials and Methods: This was a randomized clinical trial conducted in Shiraz University infertility clinic of Ghadir hospital. A total of 217 women with unexplained infertility aged 23-35 years old were randomly divided into two study groups through block randomization. After superovulation by clomiphene-citrate and gonadotropins and when the dominant follicles reached 18-20 mm, patients were randomly assigned to undergo endometrial local injury at posterior uterine wall by piplle endometrial sampling (n=114) or mock pipette biopsy (n=103) during pre-ovulatory days (when spontaneous urinary LH surge was detected). Then all the patients were instructed to follow a regularly timed intercourse.
Results: The pregnancy rate was significantly higher in the endometrial injury group compared to the control group [17/114 (14.9%) vs. 6/103 (5.8%) (OR: 2.83 95% CI: 1.07-7.49, p=0.03]. The abortion rate was comparable between two groups (17.64% vs. 14.28%; p=0.701).
Conclusion: Local mechanical injury of the endometrium can enhance the uterine receptivity and facilitates the embryo implantation. This simple, easy, and cost effective procedure is worth considering in selective unexplained infertility patients who implantation failure is the likely causes of infertility before complex treatments. This procedure may help reduce psychological tensions and high expenses imposed through such interventions.
Leila Amini, Najmeh Tehranian, Mansoureh Movahedin, Fahimeh Ramezani Tehrani, Saeideh Ziaei,
Volume 13, Issue 1 (1-2015)

Background: Recently there is a focus on the antioxidants as adjuvant treatment of polycystic ovary syndrome (PCOS), the most endocrinopathy in reproductive age women.
Objective: The aim of this review is answer to the question whether antioxidants are effective for managing of hormonal and metabolic problems in women with PCOS based on first degree evidences from Iran.
Materials and Methods: A systematic review of clinical trials was done in Persian and international databases including PubMed, Scientific Information Database, Google Scholar, Iran Medex, and Magiran up to 2013. Keywords were including polycystic ovary syndrome, Iran, vitamin, antioxidant. From 440 potential studies found electronically, 11 studies; including 444 women in intervention and 390 women in control groups. Intervention in three studies was Calcium-vitamin D or calcitriol; in three studies was ω-3 fatty acids; in two studies was N-acetyl cysteine; in one study was folic acid; in one study was Zinc; and in one study was Soy.
Results: Finally, 11 studies that were relevant and met the inclusion criteria reviewed. There were 7 studies in English and 4 studies in Persian. We couldn’t include all studies because all full texts were not accessible.
Conclusion: The results showed that antioxidants and vitamins have positive effects on management of PCOS women. Although it seems more studies is necessary in this field.
Mahtab Moti, Leila Amini, Soheila Sadat Mirhoseini Ardakani, Sara Kamalzadeh, Masoomeh Masoomikarimi, Moslem Jafarisani,
Volume 13, Issue 6 (8-2015)

Background: Polycystic ovary syndrome (PCOS) is a common disorder of infertility which affects more than 100 million women. It is characterized by chronic anovulation, hyper androgenism and obesity. PCOS is also associated with oxidative stress changes.
Objective: Here, we aimed to investigate the level of antioxidants and oxidative stress in Iranian women with PCOS as a predictive factor for cardiovascular disease for the first time in Iran.
Materials and Methods: In this cross sectional study 30 women with PCOS and 30 healthy women were included. C-reactive protein, serum insulin, advanced oxidation protein products, and level of total antioxidants status were measured from blood samples.
Results: The levels of serum insulin, C-reactive protein, advanced oxidation protein productswere significantly increased in women with PCOS compared with healthy women but there was a decrease in level of total antioxidants status in PCOS women.
Conclusion: These changes show that oxidative stress contributes to PCOS and the decrease of antioxidants leads to increase of oxidation products contributing to PCOS.
Ebrahim Amini, Reza Asadpour, Leila Roshangar, Razi Jafari-Joozani,
Volume 14, Issue 4 (4-2016)

Background: Linoleic acid (LA) is a polyunsaturated fatty acid present in high concentrations in follicular fluid, when added to maturation culture media, it affects oocyte competence.
Objective: In the present study, we investigated effect of linoleic acid supplementation on in vitro maturation, embryo development and apoptotic related gene expression in ovine
Materials and Methods: The experiments conducted on 450 ovine Cumulus-oocyte complexes (COCs) with homogenous ooplasm and more than two compact layers of cumulus cells. For in vitro maturation COCs were randomly allocated into four treatment groups for 24 hr period. Treatment groups were as follow: control maturation media, 0 μM LA, 50 μM LA, 100 μM LA and 200 μM LA. The cumulus cell expansion and blastocysts rates were recorded. Total RNA was isolated from embryo pools, reverse transcribed into cDNA, and subjected to apoptotic gene expression by real-time PCR.
Results: Highest concentration (200 μM/mL) of LA significantly decreased the rate of fully expanded cumulus cells 24 hr after in vitro maturation (IVM) and the percentage of blastocyste rate compared with the control (p<0.05). These inhibitory effects were associated with an increased in relative mRNA expression of Bax (Bcl-2- associated X) gene compared with controls.
Conclusion: Data obtained in present study suggest that low concentration of LA used for maturation had no deleterious effect on subsequent embryonic development compared to high concentration of LA. Relative expression of Bcl-2 (B-cell lymphoma 2) and Bax in embryos seems to be associated with LA concentration
Mahin Jamshidi Makiani, Sara Minaeian, Soheila Amini Moghaddam, Seyed Akbar Moosavi, Zahra Moeini, Vajihe Zamani, Mahnaz Karbalaei Sabbagh, Hosein Forghani,
Volume 15, Issue 5 (6-2017)

Background: Human papilloma virus (HPV) is one of the major public healthproblems and the main causes of cervical cancer. The prevalence HPV infection indeveloping countries with low financial resources is high.
Objective: This study aimed to determine the relative frequency of HPV genotypesand its sociodemographic characteristics in women referred to a general hospital inTehran, Iran from 2014-2015.
Materials and Methods: This cross-sectional study was performed in 400 womenwith Pap smear samples, referring to to a general hospital in Tehran, Iran from 2014-2015. The detection of 28 HPV genotypes was performed by using the MultiplexPCR technique. The sociodemographic survey was conducted for each HPV positivewoman.
Results: HPV-positive infection was detected in 155 (38.75%) women aged 17-85years. HPV 16 (19.1%) was the most prevalent type, followed by HPV 39 (12.5%)and HPV 18 (8.9%). The highest rate of HPV infection was observed at the age of36 years (7.7%). The level of education and economic situation of each woman wereshowed most of HPV-positive women had a high school diploma (34.6%) andaverage economic situation (67,9%). 60.9% of these women were a housewife, and67.3% lived in the capital .
Conclusion: Determination of HPV genotype and risk factor related to HPVinfection in each geographical region can lead to the production of effectivevaccines against the HPV virus. It can also be useful for disease management andhigh sensitivity diagnosis of cervical intraepithelial neoplasia.
Payam Amini, Saman Maroufizadeh, Reza Omani Samani,
Volume 15, Issue 5 (6-2017)

Background: The hospital anxiety and depression scale (HADS) is a commonscreening tool designed to measure the level of anxiety and depression in differentfactor structures and has been extensively used in non-psychiatric populations andindividuals experiencing fertility problems.
Objective: The aims of this study were to evaluate the factor structure, itemanalyses, and internal consistency of HADS in Iranian infertile patients.
Materials and Methods: This cross-sectional study included 651 infertile patients(248 men and 403 women) referred to a referral infertility Center in Tehran, Iranbetween January 2014 and January 2015. Confirmatory factor analysis was used todetermine the underlying factor structure of the HADS among one, two, and threefactormodels. Several goodness of fit indices were utilized such as comparative,normed and goodness of fit indices, Akaike information criterion, and the root meansquared error of approximation. In addition to HADS, the Satisfaction with LifeScale questionnaires as well as demographic and clinical information wereadministered to all patients.
Results: The goodness of fit indices through CFAs exposed that three and one-factormodel provided the best and worst fit to the total, male and female datasetscompared to the other factor structure models for the infertile patients. TheCronbach’s alpha for anxiety and depression subscales were 0.866 and 0.753respectively. The HADS subscales significantly correlated with SWLS, indicating anacceptable convergent validity.
Conclusion: The HADS was found to be a three-factor structure screeninginstrument in the field of infertility.
Soheila Arefi, Elham Fazeli, Manijeh Esfahani, Nasim Borhani, Nazila YAmini, Ahmad Hosseini, Fattaneh Farifteh,
Volume 16, Issue 5 (May 2018)

Background: Family of colony-stimulating factors (CSF) have an essential role on early cross talk between embryo and uterine endometrium.
Objective: The aim of this study was to evaluate the effects of the single dose of Granulocyte-CSF (G-CSF) injection on clinical outcome of assisted reproductive technology cycle in patients with repeated implantation failures.
Materials and Methods: This randomized control trial study was performed on 52 infertile women who referred to the clinic with the history of more than three previous In vitro fertilization/Intracytoplasmic sperm injection-embryo transfer failures. All patients were stimulated with standard long protocol. All embryos were transferred on day five in blastocyst stage in both groups. The treated group received 300 μg (0.5 ml) recombinant human G-CSF subcutaneously which was injected 30 min before blastocyst embryo transfer.
Results: There was not statistically significant differences in abortion rate in G-CSF and control group (p=0.09). G-CSF treated group showed higher clinical pregnancy rate in comparison with control group (56.2% vs. 40.0%) but it was not statistically significant (p=0.09). Although live birth rate in G-CSF group was higher than control group (53.1% vs. 35.0%) but there wasn’t statistically significant difference in the overall live birth rate between the two groups (p=0.10). G-CSF group had a twin pregnancies while in control group there was no twin pregnancy.
Conclusion: Our result demonstrates the possibility that pregnancy outcome is better in women with repeated unexplained In vitro fertilization failure who are treated with G-CSF.
Sepideh Khodaverdi, Soheila Amini-Moghaddam, Fariba Almassi Nokiani , Neda Hashemi , Robabeh Mohammad Beigi ,
Volume 16, Issue 6 (Jun 2018)

Background: It has been shown that Carbohydrate antigen (CA) 125 and CA 19-9 tumor markers are useful for diagnosis and follow up of ovarian carcinoma.
Case: In this case, we reported the high level of CA-125 and CA 19-9 with large right ovarian intact endometrioma and extensive involvement of omentum. Conclusion: Human Epididymis protein (HE4) and Risk of ovarian malignancy algorithm (ROMA) can be useful in differentiation between malignancies and benign pathologies with a good sensitivity and specificity value
Ashraf Moini, Zohreh Lavasani, Ladan Kashani, Maryam Farid Mojtahedi, Nazila YAmini,
Volume 17, Issue 9 (September 2019)

Background: Ovarian stimulation (OS) for poor ovarian response (POR) patients is still a major challenge in assisted reproductive techniques. Aromatase inhibitors as co-treatment in antagonist protocol are suggested to these patients, but there are controversial reports.
Objective: To evaluate the effectiveness Letrozole (LZ) as adjuvant treatment in gonadotropin-releasing hormone (GnRH)-antagonist protocol in POR patients undergoing in vitro fertilization/ intracytoplasmic sperm injection cycles.
Materials and Methods: This double-blind randomized clinical trial was conducted in Arash womenchr('39')s hospital. One hundred sixty infertile women with POR based on Bologna criteria were allocated into two groups randomly: LZ + GnRH-antagonist (LA) and placebo + GnRH-antagonist (PA) groups. In the experimental group, the patients received 5 mg LZ on the first five days of OS with 150 IU of recombinant human follicle-stimulating hormone (rFSH) and 150 IU of human menopausal gonadotropin (HMG). The cycle outcomes were compared between groups.
Result: The total number of retrieved oocytes and the metaphase II oocytes in LA-treated group were significantly higher than those in the control group (p = 0.008, p = 0.002). The dosage of hMG used and the duration of OS and antagonist administration in LZ-treated group were significantly lower than those of the control group. The number of patients with no oocyte, in the control group, was higher than the LZ-treated group, and the clinical pregnancy rate in LA-treated group (25%) was higher than the control group (18%); however, the differences were not significant statistically.
Conclusion: Adding 5 mg of LZ to rFSH/hMG antagonist protocol may improve the in vitro fertilization/intracytoplasmic sperm injection cycle outcome in POR patients.
Masoud Najafi, Mohsen Cheki, Peyman Amini, Abdolreza Javadi, Dheyauldeen Shabeeb, Ahmed Eleojo Musa,
Volume 17, Issue 12 (December 2019)

Background: Testis is one of the most sensitive organs against the toxic effect of ionizing radiation. Exposure to even a low dose of radiation during radiotherapy, diagnostic radiology, or a radiological event could pose a threat to spermatogenesis. This may lead to temporary or permanent infertility or even transfer of genomic instability to the next generations.
Objective: In this study, we evaluated the protective effect of treatment with three natural antioxidants; resveratrol, alpha lipoic acid, and coenzyme Q10 on radiation-induced spermatogenesis injury.
Materials and Methods: 30 NMRI mice (6-8 wk, 30 ± 5 gr) were randomly divided into six groups (n=5/each) as 1) control; 2) radiation; 3) radiation + resveratrol; 4) radiation + alpha lipoic acid; 5) radiation + resveratrol + alpha lipoic acid; and 6) radiation+ Q10. Mice were treated with 100 mg/kg resveratrol or 200 mg/kg alpha lipoic acid or a combination of these drugs. Also, Q10 was administered at 200 mg/kg. All treatments were performed daily from two days before to 30 min before irradiation. Afterward, mice were exposed to 2 Gy 60Co gamma rays; 37 days after irradiation, the testicular samples were collected and evaluated for histopathological parameters.
Results: Results showed that these agents are able to alleviate some toxicological parameters such as basal lamina and epididymis decreased sperm density. Also, all agents were able to increase Johnsen score. However, they could not protect against radiation-induced edema, atrophy of seminiferous tubules, and hyperplasia in Leydig cells.
Conclusion: This study indicates that resveratrol, alpha-lipoic acid, and Q10 have the potential to reduce some of the side effects of radiation on mice spermatogenesis. However, they cannot protect Leydig cells as a source of testosterone and seminiferous tubules as the location of sperm maturation.
Parichehr Pooransari, Atefeh Ebrahimi, Nataliya Nazemi, Fariba YAminifar, Zhila Abediasl,
Volume 18, Issue 6 (June 2020)

Background: The relation of placental gross morphology and the outcome of pregnancies complicated with diabetes mellitus in comparison with healthy pregnancies is not known. Identifying significant differences in pregnancy outcomes in Gestational Diabetes Mellitus (GDM) and healthy pregnancies by the means of morphologic measurements can induce the use of antenatal ultrasonography of placental parameters to predict pregnancy outcomes.
Objective: This study aimed to evaluate the relationship between placental morphological parameters of the placenta and cord and the outcomes of pregnancies complicated with diabetes mellitus.
Materials and Methods: In this case-control study, which was conducted at two referral perinatology center in Tehran between March 2017 and November 2018, 60 pregnant women with GDM who were controlled with either diet or insulin as the case group and 60 pregnant women without GDM as the control group were enrolled. The study population were selected from patients who had their prenatal care and delivery in Mahdieh and Shohadaye Tajrish Hospital. The data was collected by taking sickness history, using data from patients files, and measuring of placental and newborn parameters after delivery. GDM was diagnosed either by 75 gr or 100 gr oral glucose tolerance tests. Placenta parameters, umbilical cord features, and newborn outcomes were compared between the two groups.
Results: Placental weight, diameter, number of lobes, thickness, placental weight to-newborn weight ratio, place of umbilical cord insertion, length, coiling, and diameter of the umbilical cord are similar in two groups. Newborn weight, NICU admission, ABG, and Apgar score are also the same in well-controlled GDM pregnancy and pregnancy without GDM.
Conclusion: Good controlled GDM causes no difference in placental gross morphology and pregnancy outcome compared to a healthy pregnancy.

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