Volume 11, Issue 1 (4-2013)                   IJRM 2013, 11(1): 77-0 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Aflatoonian N, Eftekhar M, Aflatoonian B, Rahmani E, Aflatoonian A. Surrogacy as a good option for treatment of repeated implantation failure: a case series. IJRM. 2013; 11 (1) :77-0
URL: http://journals.ssu.ac.ir/ijrmnew/article-1-337-en.html
1- Madar Hospital, Yazd, Iran, Iran
2- Department of Obstetrics and Gynecology, Yazd Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran, Iran , eftekhar@ssu.ac.ir
3- Department of Obstetrics and Gynecology, Bushehr University of Medical Sciences, Bushehr, Iran, Iran
Abstract:   (102 Views)
Background: Repeated implantation failure (RIF) is defined as pregnancy failure after two to six times with at least ten high grade embryo transfer to uterus. A variety of causes have been anticipated for RIF, including anatomical, autoimmune, genetics, endocrine and thrombotic anomalies. Factors responsible for RIF have important implication regarding treatment however in many couples a perfect cause cannot be found.
Cases: In these case series, we reported nine couples with RIF that after investigation no definitive etiology was found for RIF and empirical therapy by heparin, aspirin and or immunotherapy was not effective. In these cases we recommended transfer of embryos to surrogate uterus. Nine patients were studied and six of them developed a normal pregnancy (pregnancy rate=66.66%).
Conclusion: This study showed that surrogacy is a good option for treatment of RIF.
Full-Text [PDF 334 kb]   (34 Downloads) |   |   Full-Text (HTML)  (2 Views)  
Type of Study: Original Article |
Received: 2017/10/1 | Accepted: 2018/02/25 | Published: 2018/02/25

References
1. Margalioth E, Ben-Chetrit A, Gal M, Eldar-Geva T. Investigation and treatment of repeated implantation failure following IVF-ET. Hum Reprod 2006; 21: 3036-3043. [DOI:10.1093/humrep/del305]
2. Penzias AS. Recurrent IVF failure: other factors. Fertil Steril 2012; 97: 1033-1038. [DOI:10.1016/j.fertnstert.2012.03.017]
3. Vaquero E, Lazzarin N, Caserta D, Valensise H, Baldi M, Moscarini M, et al. Diagnostic evaluation of women experiencing repeated in vitro fertilization failure. Eur J Obstet Gynecol Reprod Biol 2006; 125: 79-84. [DOI:10.1016/j.ejogrb.2005.08.001]
4. Strowitzki T, Germeyer A, Popovici R, Von Wolff M. The human endometrium as a fertility-determining factor. Hum Reprod Update 2006; 12: 617-630. [DOI:10.1093/humupd/dml033]
5. Revel A. Defective endometrial receptivity. Fertil Steril 2012; 97: 1028-1032. [DOI:10.1016/j.fertnstert.2012.03.039]
6. Tan BK, Vandekerckhove P, Kennedy R, Keay SD. Investigation and current management of recurrent IVF treatment failure in the UK. BJOG 2005; 112: 773-780. [DOI:10.1111/j.1471-0528.2005.00523.x]
7. Simon A, Laufer N. Repeated implantation failure: clinical approach. Fertil Steril 2012; 97: 1039-1043. [DOI:10.1016/j.fertnstert.2012.03.010]
8. Coulam CB, Roussev RG. Correlation of NK cell activation and inhibition markers with NK cytoxicity among women experiencing immunologic implantation failure after in vitro fertilization and embryo transfer. J Assist Reprod Genet 2003; 20: 58-62. [DOI:10.1023/A:1021736007376]
9. Yanaihara A, Iwasaki S, Okai T. Causes and Treatment of Implantation Failure. Taiwan J Obstet Gynecol 2005;44:26-30. [DOI:10.1016/S1028-4559(09)60102-9]
10. Kling C, Schmutzler A, Wilke G, Hedderich J, Kabelitz D. Two-year outcome after recurrent implantation failure: prognostic factors and additional interventions. Arch Gynecol Obstet 2008; 278: 135-142. [DOI:10.1007/s00404-007-0538-7]
11. Carp HJ, Dirnfeld M, Dor J, Grudzinskas JG. ART in recurrent miscarriage: preimplantation genetic diagnosis/screening or surrogacy? Hum Reprod 2004; 19: 1502-1505.
12. Tremellen K, Russell P. Adenomyosis is a potential cause of recurrent implantation failure during IVF treatment. Aust N Z J Obstet Gynaecol 2011; 51: 280-283. [DOI:10.1111/j.1479-828X.2010.01276.x]
13. Garrido-Gómez T, Dominguez F, Simón C. Proteomics of embryonic implantation. Handb Exp Pharmacol 2010:67-78.

Add your comments about this article : Your username or Email:
CAPTCHA code

Send email to the article author


© 2018 All Rights Reserved | International Journal of Reproductive BioMedicine

Designed & Developed by : Yektaweb