Volume 16, Issue 2 (February 2018)                   IJRM 2018, 16(2): 93-100 | Back to browse issues page


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Ghiasvand T, Goodarzi M T, Shafiee G, Zamani A, Karimi J, Ghorbani M et al . Association between seminal plasma neopterin and oxidative stress in male infertility: A case-control study. IJRM. 2018; 16 (2) :93-100
URL: http://journals.ssu.ac.ir/ijrmnew/article-1-970-en.html
1- Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan Iran
2- Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan Iran , mt.goodarzi@umsha.ac.ir
3- Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
4- Endometer and Endometriosis Centre, Fatemieh Hospital, Hamadan University of Medical Sciences, Hamadan, Iran
Abstract:   (1409 Views)
Background: Neopterin is a significant and sensitive marker in estimating the activity of cellular immune system. Oxidative stress plays a role in the etiology of male infertility. Increased reactive oxygen species is accompanied with increase in neopterin level. Hence neopterin may be involved in male infertility.
Objective: The objective of this case-control study was to determine neopterin level in idiopathic infertile and normospermic men; furthermore, to identify its relationship with oxidative stress markers including total oxidant, malondialdehyde, sperm DNA fragmentation, and total antioxidant capacity of seminal plasma.
Materials and Methods: Forty seven infertile and forty three normospermic males were selected according to WHO criteria. Their semen and blood samples were taken; subsequently, the levels of neopterin, total oxidant, total antioxidant, malondialdehyde, and sperm DNA fragmentation were measured.
Results: The levels of neopterin, total oxidant, and malondialdehyde in seminal plasma of infertile males were significantly higher than those of normospermic group (p=0.038, 0.018, and 0.028, respectively). Furthermore, sperm DNA fragmentation in infertile men was higher than that of control group (p<0.001). Moreover, total antioxidant capacity of seminal plasma in infertile males was significantly lower than that of normospermic subjects (p=0.002). No significant difference was observed in serum neopterin, total oxidant, and malondialdehyde between the infertile and normospermic groups.
Conclusion: The significant inverse correlation between seminal plasma neopterin and total antioxidant in the infertile males supports a possible role of neopterin in male infertility. Neopterin can be suggested as a marker in monitoring and diagnosis of idiopathic male infertility.
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Type of Study: Original Article |

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