Volume 15, Issue 7 (8-2017)                   IJRM 2017, 15(7): 391-402 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Maleki-Saghooni N, Amirian M, Sadeghi R, Latifnejad Roudsari R. Effectiveness of infertility counseling on pregnancy rate in infertile patients undergoing assisted reproductive technologies: A systematic review and meta-analysis. IJRM. 2017; 15 (7) :391-402
URL: http://journals.ssu.ac.ir/ijrmnew/article-1-841-en.html
1- Student Research Committee, Department of Midwifery, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran
2- Department of Obstetrics and Gynecology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3- Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
4- Evidence-Based Care Research Center, Department of Midwifery, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran , latifnejadr@mums.ac.ir
Abstract:   (990 Views)
Background: Psychological interventions such as counseling for infertile patients seem to increase pregnancy rate.
Objective: The aim of this systematic review and meta-analysis was to examine if counseling improves pregnancy rate among infertile patients. Thus, randomized controlled trials investigating the effect of counseling on pregnancy rate in infertile patients undergoing ART were pooled in a meta-analysis.
Materials and Methods: The databases of PubMed, Scopus, Cochrane, Google Scholar, and Persian databases including SID, Iran Medex, and Magiran were searched from 1997 to July 2016 to identify relevant articles. Included studies were trials on infertile patients (women or couples) receiving counseling independent of actual medical treatment. The outcome measure was pregnancy rate. Out of 620 relevant published trials, a total of nine RCTs were ultimately reviewed systematically and included in a meta-analysis to measure the efficacy of counseling on pregnancy rate. Odds ratio and Risk difference were calculated for pregnancy rate. All statistical analyses were done by Comprehensive Meta-analysis Version 2.
Results: Nine RCTs involving 1079 infertile women/couples were included in the study. The findings from RCTs indicated significant effect of counseling on pregnancy rate so that there was a positive impact of counseling on pregnancy rate (OR= 3.852; 95% CI: 2.492-5.956; p=0.00) and (RD= 0.282; 95%; CI: 0.208-0.355; p=0.00).
Conclusion: Counseling was found to improve patients’ chances of becoming pregnant. So counseling represents an attractive treatment option, in particular, for infertile patients who are not receiving medical treatments.
Full-Text [PDF 650 kb]   (253 Downloads) |   |   Full-Text (HTML)  (52 Views)  
Type of Study: Original Article |

1. Menning BE. The infertile couple: a plea for advocacy. Child Welfare 1975; 54: 454-460.
2. Sherrod RA. Understanding the emotional aspects of infertility: implications for nursing practice. J Psychosoc Nurs Mental Health Serv 2004; 42: 41-47.
3. Bartlam B, McLeod J. Infertility Counselling: the ISSUE experience of setting up a telephone counselling service. Patient Educ Couns 2000; 41: 313-321. [DOI:10.1016/S0738-3991(99)00115-9]
4. Cooper SL, Glazer ES. Beyond Infertility: the new paths to parenthood. 2nd Ed. New York, Lexington; 1994.
5. Dunkel-Schetter C LMPrtiI SA, Dunkel-Schetter C. Infertility: Perspectives from Stress and Coping Research. New York, Plenum Press; 1991: 29-57.
6. Cousineau TM, Domar AD. Psychological impact of infertility. Best Pract Res Clin Obstet Gynaecol 2007; 21: 293-308. [DOI:10.1016/j.bpobgyn.2006.12.003]
7. Moreira SdNT, Melo COM, Tomaz G, Azevedo GDd. Estresse e ansiedade em mulheres inférteis. Rev Bras Ginecol Obstet 2006; 28: 358-364.
8. Wichman CL, Ehlers SL, Wichman SE, Weaver AL, Coddington C. Comparison of multiple psychological distress measures between men and women preparing for in vitro fertilization. Fertil Steril 2011; 95: 717-721. [DOI:10.1016/j.fertnstert.2010.09.043]
9. Verhaak CM, Smeenk J, Evers A, Kremer J, Kraaimaat F, Braat D. Women's emotional adjustment to IVF: a systematic review of 25 years of research. Hum Reprod Update 2007; 13: 27-36. [DOI:10.1093/humupd/dml040]
10. Demyttenaere K, Bonte L, Gheldof M, Vervaeke M, Meuleman C, Vanderschuerem D, et al. Coping style and depression level influence outcome in in vitro fertilization. Fertil Steril 1998; 69: 1026-1033. [DOI:10.1016/S0015-0282(98)00089-2]
11. Smeenk J, Verhaak C, Eugster A, Van Minnen A, Zielhuis G, Braat D. The effect of anxiety and depression on the outcome of in-vitro fertilization. Hum Reprod 2001; 16: 1420-1423. [DOI:10.1093/humrep/16.7.1420]
12. Domar AD, Broome A, Zuttermeister PC, Seibel M, Friedman R. The prevalence and predictability of depression in infertile women. Fertil Steril 1992; 58: 1158-1163. [DOI:10.1016/S0015-0282(16)55562-9]
13. Demyttenaere K, Nijs P, Steeno O, Koninckx P, Evers-Kiebooms G. Anxiety and conception rates in donor insemination. J Psychosom Obstet Gynecol 1988; 8: 175-181. [DOI:10.3109/01674828809016785]
14. Rodriguez B, Bermudez L, Poncede Leon E, Castro L. The relationship between infertility and anxiety: some preliminary findings. Third world congress of behavior therapy; 1983.
15. Sarrel P, DeCherney AH. Psychotherapeutic intervention for treatment of couples with secondary infertility. Fertil Steril 1985; 43: 897-900. [DOI:10.1016/S0015-0282(16)48618-8]
16. Klonoff-Cohen H, Chu E, Natarajan L, Sieber W. A prospective study of stress among women undergoing in vitro fertilization or gamete intrafallopian transfer. Fertil Steril 2001; 76: 675-687. [DOI:10.1016/S0015-0282(01)02008-8]
17. Ponjaert-Kristoffersen I, Baetens P. Counselling patients with infertility problems. Int J Adv Couns 1999; 21: 249-261. [DOI:10.1023/A:1005407918369]
18. Blyth E. Guidelines for infertility counselling in different countries: Is there an emerging trend? Hum Reprod 2012; 27: 2046-2057. [DOI:10.1093/humrep/des112]
19. Roudsari RL, Allan HT. Women's experiences and preferences in relation to infertility counselling: a multifaith dialogue. Int J Fertil Steril 2011; 5: 158.
20. Boivin J. A review of psychosocial interventions in infertility. Soc Sci Med 2003; 57: 2325-2341. [DOI:10.1016/S0277-9536(03)00138-2]
21. Van den Broeck U, Emery M, Wischmann T, Thorn P. Counselling in infertility: individual, couple and group interventions. Patient Educ Couns 2010; 81: 422-428. [DOI:10.1016/j.pec.2010.10.009]
22. Li J, Long L, Liu Y, He W, Li M. Effects of a mindfulness-based intervention on fertility quality of life and pregnancy rates among women subjected to first in vitro fertilization treatment. Behav Res Ther 2016; 77: 96-104. [DOI:10.1016/j.brat.2015.12.010]
23. Gorayeb R, Borsari AC, Rosa-e-Silva ACJ, Ferriani RA. Brief cognitive behavioral intervention in groups in a Brazilian assisted reproduction program. Behav Med 2012; 38: 29-35. [DOI:10.1080/08964289.2012.654834]
24. Chan CH, Ng EH, Chan CL, Chan TH. Effectiveness of psychosocial group intervention for reducing anxiety in women undergoing in vitro fertilization: a randomized controlled study. Fertil Steril 2006; 85: 339-346. [DOI:10.1016/j.fertnstert.2005.07.1310]
25. Frederiksen Y, Farver-Vestergaard I, Skovgård NG, Ingerslev HJ, Zachariae R. Efficacy of psychosocial interventions for psychological and pregnancy outcomes in infertile women and men: a systematic review and meta-analysis. BMJ 2015; 5: e006592. [DOI:10.1136/bmjopen-2014-006592]
26. Speroff L, Robert H. Clinical gynecologic endocrinology and infertility. 6th Ed. Philadelphia, Robert-D; 2005
27. de Klerk C, Hunfeld J, Duivenvoorden H, Den Outer M, Fauser B, Passchier J, et al. Effectiveness of a psychosocial counselling intervention for first-time IVF couples: a randomized controlled trial. Hum Reprod 2005; 20: 1333-1338. [DOI:10.1093/humrep/deh748]
28. Hosaka T, Matsubayashi H, Sugiyama Y, Izumi S-i, Makino T. Effect of psychiatric group intervention on natural-killer cell activity and pregnancy rate. Gen Hosp Psychiatr 2002; 24: 353-356. [DOI:10.1016/S0163-8343(02)00194-9]
29. Terzioglu F. Investigation into effectiveness of counseling on assisted reproductive techniques in Turkey. J Psychosom Obstet Gynecol 2001; 22: 133-141. [DOI:10.3109/01674820109049965]
30. Ramezanzadeh F, Noorbala A-A, Abedinia N, Forooshani AR, Naghizadeh MM. Psychiatric intervention improved pregnancy rates in infertile couples. Malays J Med Sci 2011; 18:16-24.
31. Domar AD, Rooney KL, Wiegand B, Orav EJ, Alper MM, Berger BM, et al. Impact of a group mind/body intervention on pregnancy rates in IVF patients. Fertil Steril 2011; 95: 2269-2273. [DOI:10.1016/j.fertnstert.2011.03.046]
32. Domar AD, Clapp D, Slawsby EA, Dusek J, Kessel B, Freizinger M. Impact of group psychological interventions on pregnancy rates in infertile women. Fertil Steril 2000; 73: 805-811. [DOI:10.1016/S0015-0282(99)00493-8]
33. De Liz T, Strauss B. Differential efficacy of group and individual/couple psychotherapy with infertile patients. Hum Reprod 2005; 20: 1324-1332. [DOI:10.1093/humrep/deh743]
34. Hämmerli K, Znoj H, Barth J. The efficacy of psychological interventions for infertile patients: a meta-analysis examining mental health and pregnancy rate. Hum Reprod Update 2009; 15: 279-295. [DOI:10.1093/humupd/dmp002]
35. Erica M. Taylor. The stress of infertility. Hum Ecol 2002; 95: 12.
36. Lok IH, Lee DTS, Cheung LP, Chung WS, Lo WK, Haines CJ. Psychiatric morbidity amongst infertile Chinese women undergoing treatment with assisted reproductive technology and the impact of treatment failure. Gynecol Obstet Invest 2002; 53: 195-199. [DOI:10.1159/000064560]
37. Verhaak C, Lintsen A, Evers A, Braat D. Who is at risk of emotional problems and how do you know? Screening of women going for IVF treatment. Hum Reprod 2010; 25: 1234-1240. [DOI:10.1093/humrep/deq054]
38. Yong P, Martin C, Thong J. A comparison of psychological functioning in women at different stages of in vitro fertilization treatment using the mean affect adjective check list. J Assist Reprod Genet 2000; 17: 553-556. [DOI:10.1023/A:1026429712794]
39. Heidari P, Latifnejad R, Sahebi A, Jahaniyan M, Mazloum SR. Impact of cognitive behaviour therapy on anxiety level of primary infertile women undergoing IUI. J Reprod Infertil 2002; 3: 40-51.
40. Latifnejad roudsari R RM, Moosavifar N, Modarres Gharvi M. The effect of collaborative infertility counseling on perceived stress in infertile women undergoing IVF. Iran J Obstet Gynecol Infertil 2011; 14: 22-31.
41. Facchinetti F, Volpe A, Matteo ML, Genazzani AR, Artini GP. An increased vulnerability to stress is associated with a poor outcome of in vitro fertilization-embryo transfer treatment. Fertil Steril 1997; 67: 309-314. [DOI:10.1016/S0015-0282(97)81916-4]
42. Wischmann TH. Psychogenic infertility-myths and facts. J Assist Reprod Gen 2003; 20: 485-494. [DOI:10.1023/B:JARG.0000013648.74404.9d]
43. Roudsari RL, Bidgoli MR. Collaborative Infertility Counseling and Marital Satisfaction in Infertile Females Undergoing In-Vitro Fertilization: A Randomized Controlled Trial. Nurs Midwif Stud 2017; 6: 1-7.
44. Smeenk JM, Verhaak CM, Stolwijk AM, Kremer JA, Braat DD. Reasons for dropout in an in vitro fertilization/intracytoplasmic sperm injection program. Fertil Steril 2004; 81: 262-268. [DOI:10.1016/j.fertnstert.2003.09.027]
45. Verberg M, Eijkemans M, Heijnen E, Broekmans F, de Klerk C, Fauser B, et al. Why do couples drop-out from IVF treatment? A prospective cohort study. Hum Reprod 2008; 23: 2050-2055. [DOI:10.1093/humrep/den219]

Send email to the article author

© 2020 All Rights Reserved | International Journal of Reproductive BioMedicine

Designed & Developed by : Yektaweb