Volume 14, Issue 11 (11-2016)                   IJRM 2016, 14(11): 687-690 | Back to browse issues page


XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Eftekhar M, Miraj S, Farid Mojtahedi M, Neghab N. Efficacy of Intrauterine infusion of granulocyte colony stimulating factor on patients with history of implantation failure: A randomized control trial. IJRM. 2016; 14 (11) :687-690
URL: http://journals.ssu.ac.ir/ijrmnew/article-1-707-en.html
1- Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2- Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran , dr.s.miraj@gmail.com
3- Department of Obstetrics and Gynecology, Endocrinology and Female Infertility Unit, Roointan Arash Women’s Health Research and Educational Hospital, Tehran University of Medical Sciences, Tehran, Iran
Abstract:   (598 Views)
Background: Although pregnancy rate in in vitro fertilization-embryo transfer (IVF-ET) cycles has been increased over the preceding years, but the majority of IVF-ET cycles still fail. Granulocyte colony stimulating factor (GCSF) is a glycoprotein that stimulates cytokine growth factor and induces immune system which may improve pregnancy rate in women with history of implantation failure.
Objective: The aim of this study was to evaluate GCSF ability to improve pregnancy rate in women with history of implantation failure
Materials and Methods: 0.5 ml (300 μg/ml) GCSF was infused intrauterine in intervention group. Pregnancy outcomes were assessed based on clinical pregnancy.
Results: The mean age of participants was 31.95±4.71 years old. There were no significant differences between demographic characteristics in two groups (p>0.05). The pregnancy outcome in GCSF group was improved significantly (p=0.043).
Conclusion: GCSF can improve pregnancy outcome in patients with history of implantation failure.
Full-Text [PDF 92 kb]   (155 Downloads) |   |   Full-Text (HTML)  (59 Views)  
Type of Study: Original Article |

References
1. Richter KS, Bugge KR, Bromer JG, Levy MJ. Relationship between endometrial thickness and embryo implantation, based on 1,294 cycles of in vitro fertilization with transfer of two blastocyst-stage embryos. Fertil Steril 2007; 87: 53-59. [DOI:10.1016/j.fertnstert.2006.05.064]
2. Eftekhar M, Hosseinisadat R, Baradaran R, Naghshineh E. Effect of granulocyte colony stimulating factor (G-CSF) on IVF outcomes in infertile women: An RCT. Int J Reprod Biomed 2015; 14: 341-346.
3. Traub ML, Van Arsdale A, Pal L, Jindal S, Santoro N. Endometrial thickness, Caucasian ethnicity, and age predict clinical pregnancy following fresh blastocyst embryo transfer: a retrospective cohort. Reprod Biol Endocrinol 2009; 7: 27-31. [DOI:10.1186/1477-7827-7-33]
4. Gonen Y, Casper RF. Prediction of implantation by the sonographic appearance of the endometrium during controlled ovarian stimulation for in vitro fertilization (IVF). J In Vitro Fertil Embryo Transfer 1990; 7: 146-152. [DOI:10.1007/BF01135678]
5. Margalioth E, Ben-Chetrit A, Gal M, Eldar-Geva T. Investigation and treatment of repeated implantation failure following IVF-ET. Hum Reprod 2006; 21: 3036-3043. [DOI:10.1093/humrep/del305]
6. Shufaro Y, Schenker JG. Implantation failure, etiology, diagnosis and treatment. Int J Infertil Fetal Med 2011; 2: 1-7. [DOI:10.5005/jp-journals-10016-1009]
7. Margalioth EJ, Ben-Chetrit A, Gal M, Eldar-Geva T. Investigation and treatment of repeated implantation failure following IVF-ET. Hum Reprod 2006; 21: 3036-3043. [DOI:10.1093/humrep/del305]
8. Isaacs Jr J, Wells C, Williams D, Odem R, Gast M, Strickler R. Endometrial thickness is a valid monitoring parameter in cycles of ovulation induction with menotropins alone. Fertil Steril 1996; 65: 262-266.
9. Fiedler K, Wurfel W. Effectivity of heparin in assisted reproduction. Eur J Med Res 2004; 9: 207-214.
10. Broekmans FJ, Kwee J, Hendriks DJ, Mol BW, Lambalk CB. A systematic review of tests predicting ovarian reserve and IVF outcome. Hum Reprod Update 2006; 12: 685-718. [DOI:10.1093/humupd/dml034]
11. Al-Ghamdi A, Coskun S, Al-Hassan S, Al-Rejjal R, Awartani K. The correlation between endometrial thickness and outcome of in vitro fertilization and embryo transfer (IVF-ET) outcome. Reprod Biol Endocrinol 2008; 6: 37. [DOI:10.1186/1477-7827-6-37]
12. Salmassi A, Schmutzler AG, Schaefer S, Koch K, Hedderich J, Jonat W, et al. Is granulocyte colony-stimulating factor level predictive for human IVF outcome? Hum Reprod 2005; 20: 2434-2440. [DOI:10.1093/humrep/dei071]
13. Rutella S, Zavala F, Danese S, Kared H, Leone G. Granulocyte colony-stimulating factor: a novel mediator of T cell tolerance. J Immunol 2005; 175: 7085-7091. [DOI:10.4049/jimmunol.175.11.7085]
14. Allahbadia G. The unfinished story of granulocyte colony-stimulating factor in assisted reproductive technology. IVF Lite 2014; 1: 139. [DOI:10.4103/2348-2907.142318]
15. Wang H, Wen Y, Polan ML, Boostanfar R, Feinman M, Behr B. Exogenous granulocyte-macrophage colony-stimulating factor promotes follicular development in the newborn rat in vivo. Hum Reprod 2005; 20: 2749-2756. [DOI:10.1093/humrep/dei123]
16. Scarpellini F, Sbracia M. Use of granulocyte colony-stimulating factor for the treatment of unexplained recurrent miscarriage: a randomised controlled trial. Hum Reprod 2009; 24: 2703-2708. [DOI:10.1093/humrep/dep240]
17. Okohue J, Onuh S, Ebeigbe P, Shaibu I, Wada I, Ikimalo J, et al. The effect of endometrial thickness on in vitro fertilization (IVF)-embryo transfer/ intracytoplasmic sperm injection (ICSI) outcome. Afr J Reprod Health 2009; 13: 113-121.
18. Gleicher N, Vidali A, Barad DH. Successful treatment of unresponsive thin endometrium. Fertil Steril 2011; 95: 2123. [DOI:10.1016/j.fertnstert.2011.01.143]
19. Gleicher N, Kim A, Michaeli T, Lee H, Shohat-Tal A, Lazzaroni E, et al. A pilot cohort study of granulocyte colony-stimulating factor in the treatment of unresponsive thin endometrium resistant to standard therapies. Hum Reprod 2013; 28: 172-177. [DOI:10.1093/humrep/des370]
20. Eftekhar M, Sayadi M, Arabjahvani F. Transvaginal perfusion of G-CSF for infertile women with thin endometrium in frozen ET program: A non-randomized clinical trial. Iran J Reprod Med 2014; 12: 661-666.
21. Wang H, Wen Y, Polan ML, Boostanfar R, Feinman M, Behr B. Exogenous granulocyte-macrophage colony-stimulating factor promotes follicular development in the newborn rat in vivo. Hum Reprod 2005; 20: 2749-2756. [DOI:10.1093/humrep/dei123]
22. Barad DH, Yu Y, Kushnir VA, Shohat-Tal A, Lazzaroni E, Lee HJ, et al. A randomized clinical trial of endometrial perfusion with granulocyte colony-stimulating factor in in vitro fertilization cycles: impact on endometrial thickness and clinical pregnancy rates. Fertil Steril 2014; 101: 710-715. [DOI:10.1016/j.fertnstert.2013.12.016]
23. Kunicki M, Lukaszuk K, Woclawek-Potocka I, Liss J, Kulwikowska P, Szczyptanska J. Evaluation of granulocyte colony-stimulating factor effects on treatment-resistant thin endometrium in women undergoing in vitro fertilization. BioMed Res Int 2014; 2014: 913235. [DOI:10.1155/2014/913235]
24. Sjoblom C, Wikland M, Robertson SA. Granulocyte-macrophage colony-stimulating factor promotes human blastocyst development in vitro. Hum Reprod 1999; 14: 3069-3076. [DOI:10.1093/humrep/14.12.3069]

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


© 2020 All Rights Reserved | International Journal of Reproductive BioMedicine

Designed & Developed by : Yektaweb