Volume 13, Issue 8 (9-2015)                   IJRM 2015, 13(8): 489-494 | Back to browse issues page

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Farhadi M, Mohseni Kouchesfahani H, Shockravi A, Foroozanfar M, Parivar K. The adverse effects of the methoxsalen and ultraviolent A radiation on spermatogenesis in mice. IJRM. 2015; 13 (8) :489-494
URL: http://journals.ssu.ac.ir/ijrmnew/article-1-674-en.html
1- Department of Mcrobiology, Karaj Branch, Islamic Azad University, Karaj, Iran , monafarhadi@yahoo.com
2- Department of Biology, Kharazmi University, Tehran, Iran
3- Faculty of Chemistry, Kharazmi University, Tehran, Iran
Abstract:   (905 Views)
Background: Different investigation showed that 5-methoxypsoralen and 8- methoxypsoralen reduce birth rates in the rats.
Objective: In this study we worked out the effect of methoxsalen together with ultraviolent A (UVA) radiation on mature Balb/C mice spermatogenesis.
Materials and Methods: The LD50 standard was determined 160 mg/kg and the UVA dose which causes erythema was calculated 0.046 J/cm2. A sub-lethal dose of 80 mg/kg of methoxsalen solution was injected intrapritoneally to mature mice and after one hour they were exposed to UVA radiation for 20 minutes. Experiments applied included methoxsalen alone, methoxsalen with UVA, UVA alone, sham group (a group received Tween 80), and control group (N=6). In all experimental groups except UVA alone group, injections were carri