Volume 12, Issue 7 (8-2014)                   IJRM 2014, 12(7): 481-0 | Back to browse issues page

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Enzevaei A, Salehpour S, Tohidi M, Saharkhiz N. Subclinical hypothyroidism and insulin resistance in polycystic ovary syndrome: is there a relationship?. IJRM. 2014; 12 (7) :481-0
URL: http://journals.ssu.ac.ir/ijrmnew/article-1-559-en.html
1- Infertility and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- Infertility and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran , saghar.salehpour@yahoo.com
3- Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract:   (540 Views)
Background: Polycystic ovary syndrome (PCOS) is the most common hyperandrogenic disorder among women and is often defined as hyperandrogenic syndrome. These patients are at risk for oligo/amenorrhea, chronic anovulation, infertility, obesity, spontaneous abortion, insulin resistance, hyperinsulinemia and metabolic syndrome. Thyroid disorders especially hypothyroidism is more common in these people. In PCOS patients, subclinical hypothyroidism may aggravate insulin resistance.
Objective: The goal was to find any relationship between subclinical hypothyroidism and insulin resistance in PCOS patients.
Materials and Methods: In this prospective cross sectional study we included all PCOS patients coming to infertility clinic of Taleghani Hospital in 2010-2012 who had the criteria of Rotterdam for PCOS. Then the clinical examination was done for them and height, weight, body mass index and lab data were measured including thyroid hormone and biochemical profile. The data were analyzed by SPSS software version 20.
Results: Among 75 PCOS patients, 19 (25.5%) had subclinical hypothyroidism and 56 patients (74.4%) were euthyroid. The prevalence of insulin resistance was 22.7% and 77.3% of patients had no insulin resistance were normal.
Conclusion: We could find no relationship between insulin resistance and subclinical hypothyroidism in PCOS patients.
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Type of Study: Original Article |

References
1. Mueller A, Schöfl C, Dittrich R, Cupisti S, Oppelt PG, Schild RL, et al. Thyroid-stimulating hormone is associated with insulin resistance independently of body mass index and age in women with polycystic ovary syndrome. Hum Reprod 2009; 24: 2924-2930. [DOI:10.1093/humrep/dep285]
2. Speroff L. Anovulation and the Polycystic Ovary, in Clinical Gynecologic Endocrinology and Infertility. Lippincott Williams & Wilkins; 2011: 490-531.
3. Dunaif A. Insulin resistance and polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocrinol Rev 1997; 18: 774-800. [DOI:10.1210/er.18.6.774]
4. Erel CT, Senturk LM, Kaleli S, Gezer A, Baysal B, Tasan E. Is serum leptin level regulated by thyroid function, lipid metabolism and insulin resistance in poly cystic ovary syndrome? Gynecol Endocrinol 2003; 17: 223-229.
5. Huang IGM, Matthew Peterson C. Endocrine disorders, Endocrine disorders, in Gynecology BJS Editor. Lippincott Williams & Wilkins; 2007: 1069-1135.
6. Nada AM. effect of treatment of overt hypothyroidism on Insuline resistance. World J Diabetes 2013; 4: 157-161. [DOI:10.4239/wjd.v4.i4.157]
7. Ciaraldi TP, Aroda V, Mudaliar S, Chang RJ, Henry RR. Polycystic ovary syndrome is associated with tissue specific differences in insulin resistance. J Clin Endocrinol Metab 2009; 94: 157-163. [DOI:10.1210/jc.2008-1492]
8. Pallotti S, Gasbarrone A, Franzese IT. Relationship between insulin secretion, and thyroid and ovary function in patients suffering from polyystic ovary. Minerva Endocrinol 2005; 30: 193-197.
9. Uzunlulu M, Yorulmaz E, Oguz A. Prevalence of subclinical hypothyroidism in patients with metabolic syndrome. Endocr J 2007; 54: 71-76. [DOI:10.1507/endocrj.K06-124]
10. Michalakis KG, Mesen TB, Brayboy LM, Yu B, Richter KS, Levy M, et al. Subclinical elevations of thyroid-stimulating hormone and assisted reproductive technology outcomes. Fertil Steril 2011; 95: 2634-2637. [DOI:10.1016/j.fertnstert.2011.02.056]
11. Maratou E, Hadjidakis DJ, Kollias A, Tsegka K, Peppa M, Alevizaki M, et al. Studies if insulin resistance in patients with clinical and subclinical hypothyroidism. Eur J Endocrinol 2009; 160: 785-790. [DOI:10.1530/EJE-08-0797]
12. Roos A, Bakker SJ, Links TP, Gans RO, Wolffenbuttel BH. Thyroid function is associated with components of metabolic syndrome in euthyroid subjects. J Clin Endocrinol Metab 2007; 92: 491-496. [DOI:10.1210/jc.2006-1718]
13. Ganie MA, Laway BA, Wani TA, Zargar MA, Nisar S, Ahamed F, et al. Association of subclinical hypothyroidism and phenotype, insulin resistance, and lipid parameters in young women with polycystic ovary syndrome. Fertil Steril 2011; 95: 2039-2043. [DOI:10.1016/j.fertnstert.2011.01.149]
14. Celik C, Abali R, Tasdemir N, Guzel S, Yuksel A, Aksu E, et al. Is subclinical hypothyroidism contributing dyslipidemia and insulin resistance in women with polycystic ovary syndrome? Gynecol Endocrinol 2012; 28: 615-618. [DOI:10.3109/09513590.2011.650765]
15. Hosseinpanah F, Barzin M, Tehrani FR, Azizi F. The lack of association between polycystic ovary syndrome and metabolic syndrome: Iranian PCOS prevalence study. Clin Endocrinol 2011; 75: 692-697. [DOI:10.1111/j.1365-2265.2011.04113.x]
16. Tuzcu ABM, Gokalp D, Tuzun Y, Gunes K. Subclinical hypothyroidism is associated with early elevated high sensitive C-reactive protein (low grade inflammation) and fasting hyperinsulinemia. Ensocrine J 2005; 52: 89-94. [DOI:10.1507/endocrj.52.89]
17. Al Sayed A, Al Ali N, Bo Abbas Y, Alfadhli E. Subclinical hypothyroidism is associated with early insulin resistancein Kuwaiti women. Endocr J 2006; 53: 653-657. [DOI:10.1507/endocrj.K06-018]
18. Brenta G, Berg G, Arias P, Zago V, Schnitman M, Muzzio ML, et al. Lipoprotein alterations, hepatic lipase activity, and insulin sensitivity in subclinical hypothyroidism: response to L-T4 treatment. Thyroid 2007; 17: 453-460. [DOI:10.1089/thy.2006.0302]

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