Volume 12, Issue 10 (11-2014)                   IJRM 2014, 12(10): 661-0 | Back to browse issues page

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Eftekhar M, Sayadi M, Arabjahvani F. Transvaginal perfusion of G-CSF for infertile women with thin endometrium in frozen ET program: A non-randomized clinical trial. IJRM. 2014; 12 (10) :661-0
URL: http://journals.ssu.ac.ir/ijrmnew/article-1-487-en.html
1- Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2- Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran , mozhgan.sayadi82346@gmail.com
Abstract:   (4197 Views)
Background: We often see patients with a thin endometrium in ART cycles, in spite of standard and adjuvant treatments. Improving endometrial growth in patients with a thin endometrium is very difficult. Without adequate endometrial thickness these patients, likely, would not have reached embryo transfer.
Objective: We planned this study to investigate the efficacy of intrauterine granulocyte colony-stimulating factor (G-CSF) perfusion in improving endometrium, and possibly pregnancy rates in frozen-thawed embryo transfer cycles.
Materials and Methods: This is a non-randomized intervention clinical trial. Among 68 infertile patients with thin endometrium (-7 mm) at the 12th-13th cycle day, 34 patients received G-CSF. G-CSF (300 microgram/1mL) to improve endometrial thickness was direct administered by slow intrauterine infusion using IUI catheter. If the endometrium had not reached at least a 7-mm within 48-72 h, a second infusion was given. Endometrial thickness was assessed by serial vaginal ultrasound at the most expanded area of the endometrial stripe.
Results: The cycle was cancelled in the patients with thin endometrium (endometrial thickness below 7mm) until 19th cycle day ultimately The cycle cancelation rate owing to thin endometrium was similar in G-CSF group (15.20%), followed by (15.20%) in the control group (p=1.00). The endometrial growth was not different within 2 groups, an improvement was shown between controlled and G-CSF cotreated groups, with chemical (39.30% vs. 14.30%) and clinical pregnancy rates (32.10% vs. 12.00%) although were not significant.
Conclusion: Our study fails to demonstrate that G-CSF has the potential to improve endometrial thickness but has the potential to improve chemical and clinical pregnancy rate of the infertile women with thin endometrium in frozen-thawed embryo transfer cycle.
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Type of Study: Original Article |

1. Casper RF. It's time to pay attention to the endometrium. Fertil Steril 2011; 96: 519-521. [DOI:10.1016/j.fertnstert.2011.07.1096]
2. Senturk LM, Erel CT. Thin endometrium in assisted reproductive technology. Cur Opin Obstet Gynecol 2008; 20: 221-228. [DOI:10.1097/GCO.0b013e328302143c]
3. Jimenez PT, Schon SB, Odem RR, Ratts VS, Jungheim ES. A retrospective cross-sectional study: fresh cycle endometrial thickness is a sensitive predictor of inadequate endometrial thickness in frozen embryo transfer cycles. Reprod Biol Endocrinol 2013; 11: 1-5. [DOI:10.1186/1477-7827-11-35]
4. Check JH, Nowroozi K, Choe J, Dietterich C. Influence of endometrial thickness and echo patterns on pregnancy rates during in vitro fertilization. Fertil Steril 1991; 56: 1173-1175. [DOI:10.1016/S0015-0282(16)54736-0]
5. Chen MJ, Yang JH, Peng FH, Chen SU, Ho HN, Yang YS. Extended Estrogen Administration for Women with Thin Endometrium in Frozen-Thawed in-Vitro Fertilization Programs. J Assist Reprod Genet 2006; 23: 337-342. [DOI:10.1007/s10815-006-9053-1]
6. Weckstein LN, Jacobson A, Galen D, Hampton K, Hammel J. Low-dose aspirin for oocyte donation recipients with a thin endometrium: prospective, randomized study. Fertil Steril 1997; 68: 927-930. [DOI:10.1016/S0015-0282(97)00330-0]
7. Sher G, Fisch JD. Effect of vaginal sildenafil on the outcome of in vitro fertilization (IVF) after multiple IVF failures attributed to poor endometrial development. Fertil Steril 2002; 78: 1073-1076. [DOI:10.1016/S0015-0282(02)03375-7]
8. Ledee-Bataille N, Olivennes F, Lefaix J, Chaouat G, Frydman R, Delanian S. Combined treatment by pentoxifylline and tocopherol for recipient women with a thin endometrium enrolled in an oocyte donation programme. Hum Reprod 2002; 17: 1249-1253. [DOI:10.1093/humrep/17.5.1249]
9. Gleicher N, Vidali A, Barad DH. Successful treatment of unresponsive thin endometrium. Fertil Steril 2011; 95: 2123. [DOI:10.1016/j.fertnstert.2011.01.143]
10. Gleicher N, Kim A, Michaeli T, Lee H, Shohat-Tal A, Lazzaroni E, et al. A pilot cohort study of granulocyte colony-stimulating factor in the treatment of unresponsive thin endometrium resistant to standard therapies. Hum Reprod 2013; 28: 172-177. [DOI:10.1093/humrep/des370]
11. Salmassi A, Schmutzler AG, Huang L, Hedderich J, Jonat W, Mettler L. Detection of granulocyte colony-stimulating factor and its receptor in human follicular luteinized granulosa cells. Fertil Steril 2004; 81: 786-791. [DOI:10.1016/j.fertnstert.2003.09.039]
12. Calhoun DA, Lunøe M, Du Y, Christensen RD. Granulocyte colony-stimulating factor is present in human milk and its receptor is present in human fetal intestine. Pediatrics 2000; 105: e7. [DOI:10.1542/peds.105.1.e7]
13. Li Y, Pan P, Chen X, Li L, Li Y, Yang D. Granulocyte Colony-Stimulating Factor Administration for Infertile Women With Thin Endometrium in Frozen Embryo Transfer Program. Reprod Sci 2014; 21: 381-385. [DOI:10.1177/1933719113497286]
14. Kim Y, Jung Y, Jo J, Kim M, Yoo Y, Kim S. The effect of transvaginal endometrial perfusion with granulocyte colony-stimulating factor (G-CSF). Fertil Steril 2012; 98: S183. [DOI:10.1016/j.fertnstert.2012.07.673]
15. Würfel W, Santjohanser C, Hirv K, Bühl M, Meri O, Laubert I, et al. High pregnancy rates with administration of granulocyte colony-stimulating factor in ART-patients with repetitive implantation failure and lacking killer-cell immunglobulin-like receptors. Hum Reprod 2010; 25: 2151-2152. [DOI:10.1093/humrep/deq106]
16. Stamenov DS, Penkova KL, Persenska SK, Chaushev TA, Rangelov II, Baltadzhieva DN. Intracavitar uterine granulocyte-colony-stimulatory factor (G-CSF) application- A possible treatment in recurrent implantation failure. Fertil Steril 2011; 96: 93. [DOI:10.1016/j.fertnstert.2011.07.360]
17. Scarpellini F, Sbracia M. Effectiveness of GM-CSF 1 in the treatment of habitual abortion in a controlled study. Fertil Steril 2003; 80: 288. [DOI:10.1016/S0015-0282(03)01737-0]
18. Takasaki A, Ohba T, Okamura Y, Honda R, Seki M, Tanaka N, et al. Clinical use of colony-stimulating factor-1 in ovulation induction for poor responders. Fertil Steril 2008; 90: 2287-2290. [DOI:10.1016/j.fertnstert.2007.10.043]

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