Volume 10, Issue 5 (10-2012)                   IJRM 2012, 10(5): 473-0 | Back to browse issues page

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Zadehmodares S, Baheiraei N, Sharafi A, Hedayati M, Mousavi M. The ratio of cervical fluid and serum human chorionic gonadotropin as a predictor of abortion. IJRM. 2012; 10 (5) :473-0
URL: http://journals.ssu.ac.ir/ijrmnew/article-1-305-en.html
Abstract:   (751 Views)
Background: Progressions in science and technology have generated several methods for delaying preterm delivery and abortion; therefore, discovering an easy, non-invasive, practical, and non-expensive predictive factor can help us to perform preventive methods in healthy pregnant women, without any risk factors.
Objective: To indicate an appropriate index for predicting abortion in early pregnancy.
Materials and Methods: In a prospective study, 73 pregnant women who had a singleton pregnancy, had no complications or history of abortion or disease, and were referred to Mahdieh and Taleghani Hospitals between 2007-2009, were evaluated. Blood and cervical fluid samples were obtained thrice from all patients: at the first visit, after 1 week, and 1-2 weeks later. They were followed up until the 12th week of gestation.
Results: Using the receiver-operator characteristic (ROC) curve analysis, 1.62 was obtained as the cut-off point for the cervical fluid: serum human chorionic gonadotropin concentration ratio; 14 patients (19.2%) experienced abortion, and 12 women (70.6%) had a ratio ≥1.62. Of the pregnant women with a ratio of <1.62, 3.6% had an abortion.
Conclusion: Pregnant women who do not show any signs of abortion and have a high cervical fluid: serum HCG concentration ratio are at risk of abortion; therefore, the cut-off point might be an appropriate index for predicting abortion in early pregnancy.
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Type of Study: Original Article |

1. French F, Bierman JM. Probabilities of fetal mortality. Public Health Rep 1962; 77: 835-847. [DOI:10.2307/4591645]
2. Wilcox AJ, Weinberg CR, O'Connor JF, Baird DD, Schlatterer JP, Canfield RE, et al. Incidence of early loss of pregnancy. N Engl J Med 1988; 319: 189-194. [DOI:10.1056/NEJM198807283190401]
3. Tong S, Marjono B, Brown DA, Mulvey S, Breit SN, Manuelpillai U, et al. Serum concentrations of macrophage inhibitory cytokine 1 (MIC) as a predictor of miscarriage. Lancet 2004; 363: 129-130. [DOI:10.1016/S0140-6736(03)15265-8]
4. Johnson MR, Riddle AF, Sharma V, Collins WP, Nicolaides KH, Grudzinskas JG. Placental and ovarian hormones in an anembryonic pregnancy. Hum Reprod 1993; 8: 112-115. [DOI:10.1093/oxfordjournals.humrep.a137857]
5. Ioannidis G, Sacks G, Reddy N, Seyani L, Margara R, Lavery S, et al. Day 14 maternal serum progesterone levels predict pregnancy outcome in IVF/ICSI treatment cycles: a prospective study. Hum Reprod 2005; 20: 741-746. [DOI:10.1093/humrep/deh644]
6. Phipps MG, Hogan JW, Peipert JF, Lambert-Messerlian GM, Canick JA, Seifer DB. Progesterone, inhibin, and hCG multiple marker strategy to differentiate viable from nonviable pregnancies. Obstet Gynecol 2000; 95: 227-231.
7. Bischof P, Mignot TM, Cedard L. Are pregnancy-associated plasma protein-A (PAPP-A) and CA125 measurements after IVF-ET possible predictors of early pregnancy wastage? Hum Reprod 1989; 4: 843-847. [DOI:10.1093/oxfordjournals.humrep.a136998]
8. Kobayashi F, Takashima E, Sagawa N, Mori T, Fujii S. Maternal serum CA125 evels in early intrauterine and tubal pregnancies. Arch Gynecol Obstet 1993; 252: 185-189. [DOI:10.1007/BF02426356]
9. Stephen T, Budi M, Sheila M, Euan MW. Low levels of pregnancy associated plasma proteinA in asymptomatic women destined for miscarriage. Fertil Steril 2004; 82: 1468-1470. [DOI:10.1016/j.fertnstert.2004.05.078]
10. Takata K, Suganuma N, Wada H, Takeuchi K, Kitamura K, Kanayama N. Human chorionic gonadotropin in cervical fluid as a predictor of miscarriage. Fertil Steril 2005; 84: 687-691. [DOI:10.1016/j.fertnstert.2005.02.044]

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