International Journal of

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Background: Leptin is a polypeptide hormone secreted by white adipose tissue in proportion to body energy. Although the participation of leptin in female reproduction is well established any role in male reproductive function is at best tenuous. Objective: The objective of this study was to compare the leptin concentration in human seminal plasma and then the relationships between seminal leptin and semen parameters were evaluated. Materials and Methods: Semen samples were provided from 71 men; normozoospermic (n=22) asthenozoospermic (n=31) and oligoasthenozoospermic (n=18) referring to Jichi Medical University Hospital for in vitro fertilization-embryo transfer (IVF-ET) treatment. After liquefaction all sperm specimens were evaluated for sperm parameters and motility characteristics by computer-assisted semen analysis (CASA) system. After semen analysis concentrations of leptin in seminal plasma of all groups were measured by ELISA. Results: The mean concentrations of leptin in seminal plasma of normozoospermic asthenozoospermic and oligoasthenozoospermic men were 0.75+/-0.09 ng/ml 0.8+/-0.14 ng/ml and 0.8+/-0.15 ng/ml respectively. A trend was observed for a lower leptin concentration in seminal plasma of normozoospermic men compared with asthenozoospermic and oligoasthenozoospermic men. There was a significant negative correlation between seminal plasma leptin concentration with sperm motility (p

Keywords: Leptin Sperm quality Male infertility Seminal plasma Fertilization rate.

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