Volume 17, Issue 1 (January 2019)                   IJRM 2019, 17(1): 1-10 | Back to browse issues page


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Veisani Y, Jenabi E, Delpisheh A, Khazaei S. Angiogenic factors and the risk of preeclampsia: A systematic reviewand meta-analysis. IJRM. 2019; 17 (1) :1-10
URL: http://journals.ssu.ac.ir/ijrmnew/article-1-1375-en.html
1- Psychosocial Injuries Research Center, Ilam University of Medical Sciences, Ilam, Iran
2- Pediatric Developmental Disorders Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
3- Department of Clinical Epidemiology, Ilam University of Medical Sciences, Ilam, Iran
4- Research Center for Health Sciences, Hamadan University of Medical Sciences, Hamadan, Iran. , salman.khazaei61@gmail.com
Abstract:   (362 Views)
Background: The etiological nature of preeclampsia is heterogeneous. The use of biomarkers indices in early pregnancy helps to have appropriate stratification of pregnancies into high- and low risk for the purpose of choosing timely interventions.
Objective: The aim of this systematic review was to determine the pathogenic role of soluble soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) inthe prediction of preeclampsia in women.
Materials and Methods: We performed a systematic search of the international databases including PubMed, Scopus, and Web of Science until August 2017. The quality of included studies was assessed using the Newcastle-Ottawa Scale. The primary outcome in this review was preeclampsia. The statistical heterogeneity was assessed using the X2 test and quantified by I2. Pooled effects size was obtained by random effects model. Subgroup  analyses were also carried out.
Results: Totally, 284 records were identified in the initial search and 15 records were finally included in the meta-analysis. The pooled odds ratios (ORs) for the association between the high level of sFlt-1 and low level of PlGF and subsequent development of preeclampsia among women were 5.20 (95% CI: 1.24–9.16) and 2.53 (95% CI: 1.33–3.75), respectively. The mean difference for sFlt-1 and PlGF in women with preeclampsia compared to controls was 1.15 (95% CI: 0.43–1.86) and –0.94 (95% CI: –1.37–0.52),respectively.
Conclusion: According to the results from this meta-analysis, increased levels of sFlt-1 and reduced levels of PlGF predict the subsequent development of preeclampsia.
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Type of Study: Original Article |

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