Volume 16, Issue 8 (August 2018)                   IJRM 2018, 16(8): 529-534 | Back to browse issues page

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Rehman R, Mehmood M, Ali R, Shaharyar S, Alam F. Influence of body mass index and polycystic ovarian syndrome on ICSI/IVF treatment outcomes: A study conducted in Pakistani women. IJRM. 2018; 16 (8) :529-534
URL: http://journals.ssu.ac.ir/ijrmnew/article-1-1179-en.html
1- Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan, Pakistan
2- Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan., Pakistan
3- Department of Physiology, Bahria University Medical and Dental College, Bahria University medical and Dental college (BUMDC), Karachi campus, Defense Phase II, adjacent PNS Shifa Hospital., Pakistan
4- Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan., Pakistan
5- Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan, Pakistan , faiza.orakzai@gmail.com
Abstract:   (30 Views)
Background: Obesity may establish a crucial barrier for effective fertility treatment in polycystic ovary syndrome (PCOS) females.
Objective: To compare results of intra-cytoplasmic sperm injection (ICSI) in females with and without polycystic ovarian syndrome and further appraise the effect of obesity in PCOS females.
Materials and Methods: A cross-sectional study from June 2015 to July 2016 included non-PCOS and PCOS (recognized by Rotterdam criteria) females who underwent ICSI. The PCOS were further stratified into non-obese and Obese according to the South Asian criteria for body mass index. Results were categorized on the basis of beta-human chorionic gonadotropin (β-hCG) and transvaginal scan into non-pregnant (β-hCG <25 mIU/ml), preclinical abortion (β-hCG >25 mIU/ml with no fetal cardiac activity) and clinical pregnancy (β-hCG >25 mIU/ml with fetal cardiac activity on transvaginal scan). In addition, reproductive outcomes; implantation rate, clinical pregnancy rate and miscarriage rate among obese and non-obese PCOS and non-PCOS patients were compared.
Results: Our results revealed 38.5% clinical pregnancy rate in non-PCOs females, 23.8% in non-obese PCOS females whereas 26.4% in obese PCOS. Preclinical abortions were found to be highest (31.5%) in non-obese PCOS females and were the lowest (26.2%) in non-PCOS females. In non-PCOS group and non-obese PCOS females 35.4% and 44.6%, respectively, failed to become pregnant.
Conclusion: The success after ICSI in terms of number of clinical pregnancies was more in non-PCOS patients as compared to PCOS. Increase in body mass index reflected a negative impact on the reproductive outcome in PCOS patients.
Full-Text [PDF 388 kb]   (9 Downloads)    
Type of Study: Short Research Reports |
Received: 2018/08/27 | Accepted: 2018/08/27 | Published: 2018/08/27

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