Volume 16, Issue 8 (August 2018)                   IJRM 2018, 16(8): 529-534 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Rehman R, Mehmood M, Ali R, Shaharyar S, Alam F. Influence of body mass index and polycystic ovarian syndrome on ICSI/IVF treatment outcomes: A study conducted in Pakistani women. IJRM. 2018; 16 (8) :529-534
URL: http://journals.ssu.ac.ir/ijrmnew/article-1-1179-en.html
1- Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
2- Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
3- Department of Physiology, Bahria University Medical and Dental College, Bahria University medical and Dental college (BUMDC), Karachi campus, Defense Phase II, adjacent PNS Shifa Hospital
4- Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan , faiza.orakzai@gmail.com
Abstract:   (280 Views)
Background: Obesity may establish a crucial barrier for effective fertility treatment in polycystic ovary syndrome (PCOS) females.
Objective: To compare results of intra-cytoplasmic sperm injection (ICSI) in females with and without polycystic ovarian syndrome and further appraise the effect of obesity in PCOS females.
Materials and Methods: A cross-sectional study from June 2015 to July 2016 included non-PCOS and PCOS (recognized by Rotterdam criteria) females who underwent ICSI. The PCOS were further stratified into non-obese and Obese according to the South Asian criteria for body mass index. Results were categorized on the basis of beta-human chorionic gonadotropin (β-hCG) and transvaginal scan into non-pregnant (β-hCG <25 mIU/ml), preclinical abortion (β-hCG >25 mIU/ml with no fetal cardiac activity) and clinical pregnancy (β-hCG >25 mIU/ml with fetal cardiac activity on transvaginal scan). In addition, reproductive outcomes; implantation rate, clinical pregnancy rate and miscarriage rate among obese and non-obese PCOS and non-PCOS patients were compared.
Results: Our results revealed 38.5% clinical pregnancy rate in non-PCOs females, 23.8% in non-obese PCOS females whereas 26.4% in obese PCOS. Preclinical abortions were found to be highest (31.5%) in non-obese PCOS females and were the lowest (26.2%) in non-PCOS females. In non-PCOS group and non-obese PCOS females 35.4% and 44.6%, respectively, failed to become pregnant.
Conclusion: The success after ICSI in terms of number of clinical pregnancies was more in non-PCOS patients as compared to PCOS. Increase in body mass index reflected a negative impact on the reproductive outcome in PCOS patients.
Full-Text [PDF 388 kb]   (64 Downloads) |   |   Full-Text (HTML)  (28 Views)  
Type of Study: Short Research Reports |
Received: 2018/08/27 | Accepted: 2018/08/27 | Published: 2018/08/27

1. Goodman NF, Cobin RH, Futterweit W, Glueck JS, Legro RS, Carmina E. American association of clinical endocrinologists, american college of endocrinology, and androgen excess and PCOS society disease state clinical review: guide to the best practices in the evaluation and treatment of polycystic ovary syndrome-Part 2. Endocr Pract 2015; 21: 1415-1426. [DOI:10.4158/EP15748.DSCPT2]
2. Kudsy M, Alhalabi M, Al-Quobaili F. Follicular fluid Vascular Endothelial Growth Factor (VEGF) could be a predictor for pregnancy outcome in normo-responders and polycystic ovary syndrome women undergoing IVF/ICSI treatment cycles. Middle East Fertil Soc J 2016; 21: 52-56. [DOI:10.1016/j.mefs.2015.11.001]
3. Rehman R, Mustafa R, Baig M, Arif S, Hashmi MF. Use of follicular output rate to predict intracytoplasmic sperm injection outcome. Int J Fertil Steril 2016; 10: 169-174.
4. Rehman R, Syed H, Iqbal NT, Arif S, Sheharyar S. FSH/LH ratio in females and intracytoplasmic sperm injection. J Pak Med Assoc 2015; 65: 1330-1333
5. Ozgun MT, Uludag S, Oner G, Batukan C, Aygen EM, Sahin Y. The influence of obesity on ICSI outcomes in women with polycystic ovary syndrome. J Obstet Gynaecol 2011; 31: 245-249. [DOI:10.3109/01443615.2010.546906]
6. Huang K, Liao X, Dong X, Zhang H. Effect of overweight/obesity on IVF-ET outcomes in chinese patients with polycystic ovary syndrome. Int J Clin Exp Med 2014; 7: 5872-5876.
7. Alam F, Memon AS, Fatima SS. Increased body mass index may lead to hyperferritinemia irrespective of body iron stores. Pak J Med Sci 2015; 31: 1521-1526.
8. Rehman R, Hussain Z, Zahir H, Khan R. Impact of peak/mid luteal estradiol on pregnancy outcome after intracytoplasmic sperm injection. J Pak Med Assoc 2014; 64: 780-784.
9. Kondapalli LA, Molinaro TA, Sammel MD, Dokras A. A decrease in serum estradiol levels after human chorionic gonadotrophin administration predicts significantly lower clinical pregnancy and live birth rates in in vitro fertilization cycles. Hum Reprod 2012; 27: 2690-2697. [DOI:10.1093/humrep/des216]
10. Rehman R, Hussain Z, Faraz N. Effect of estradiol levels on pregnancy outcome in obese women. J Ayub Med Coll Abbottabad 2012; 24: 3-5.
11. Racowsky C, Vernon M, Mayer J, Ball GD, Behr B, Pomeroy KO, et al. Standardization of grading embryo morphology. Fertil Steril 2010; 94: 1152-1153. [DOI:10.1016/j.fertnstert.2010.05.042]
12. Pasquali R, Gambineri A, Pagotto U. The impact of obesity on reproduction in women with polycystic ovary syndrome. BJOG 2006; 113: 1148-1159. [DOI:10.1111/j.1471-0528.2006.00990.x]
13. Esinler I, Bayar U, Bozdag G, Yarali H. Outcome of intracytoplasmic sperm injection in patients with polycystic ovary syndrome or isolated polycystic ovaries. Fertil Steril 2005; 84: 932-937. [DOI:10.1016/j.fertnstert.2005.04.028]
14. Ciepiela P, Baczkowski T, Brelik P, Antonowicz A, Safranow K, Kurzawa R. Biotechnological and clinical outcome of in vitro fertilization in non-obese patients with polycystic ovarian syndrome. Folia Histochem Cytobiol 2007; 45 (Suppl.): S65-71.
15. Marquard KL, Stephens SM, Jungheim ES, Ratts VS, Odem RR, Lanzendorf S, et al. Polycystic ovary syndrome and maternal obesity affect oocyte size in in vitro fertilization/intracytoplasmic sperm injection cycles. Fertil Steril 2011; 95: 2146-2149. [DOI:10.1016/j.fertnstert.2010.10.026]
16. Wang F, Dai W, Yang XH, Guo YH, Sun YP. Analyses of optimal body mass index for infertile patients with either polycystic or non-polycystic ovary syndrome during assisted reproductive treatment in China. Sci Rep 2016; 30: 34538. [DOI:10.1038/srep34538]
17. Beydoun HA, Stadtmauer L, Beydoun MA, Russell H, Zhao Y, Oehninger S. Polycystic ovary syndrome, body mass index and outcomes of assisted reproductive technologies. Reprod Biomed Online 2009; 18: 856-863. [DOI:10.1016/S1472-6483(10)60037-5]
18. Ryan A, Wang S, Alvero R, Polotsky AJ. Prolonged gonadotropin stimulation for assisted reproductive technology cycles is associated with decreased pregnancy rates for all women except for women with polycystic ovary syndrome. J Assist Reprod Genet 2014; 31: 837-842. [DOI:10.1007/s10815-014-0253-9]
19. Cui N, Wang H, Wang W, Zhang J, Xu Y, Jiang L, et al. Impact of body mass index on outcomes of in vitro fertilization/intracytoplasmic sperm injection among polycystic ovarian syndrome patients. Cell Physiol Biochem 2016; 39: 1723-1734. [DOI:10.1159/000447873]
20. Bellver J, Ayllón Y, Ferrando M, Melo M, Goyri E, Pellicer A, et al. Female obesity impairs in vitro fertilization outcome without affecting embryo quality. Fertil Steril 2010; 93: 447-454. [DOI:10.1016/j.fertnstert.2008.12.032]
21. Rehman R, Fatima SS, Hussain M, Khan R, Khan TA. Effect of endometrial thickness on pregnancy outcome after intracytoplasmic sperm injection. J Pak Med Assoc 2015; 65: 448-451.
22. Okohue JE, Onuh SO, Ikimalo JI. Comparison of IVF/ICSI outcome in patients with polycystic ovarian syndrome or tubal factor infertility. Niger J Clin Pract 2013; 16: 207-210. [DOI:10.4103/1119-3077.110164]

Add your comments about this article : Your username or Email:

Send email to the article author

© 2019 All Rights Reserved | International Journal of Reproductive BioMedicine

Designed & Developed by : Yektaweb